
INVESTIGATION OF TLR4 POLYMORPHISM IN CHILDREN WITH VESICOURETERAL REFLUX AND RENAL SCARRING Sav NM1*, Eroz R2, Kalay Duran N3, Kilicaslan O4, Erisen Karaca S5 *Corresponding Author: *Corresponding Author: Nadide Melike SAV, Address: Duzce Universitesi Araştırma Uygulama Hastanesi, Pediatrik Nefroloji B.D, Merkez, DUZCE, TURKEY; Phone: +905378683281; Fax:+903805421390; e-mail address: savmelike@gmail.com page: 41
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REFERENCES
1.
Miyakita H, Hayashi Y, Mitsui T, Okawada M,
Kinoshita Y, Kimata T, et al. Guidelines for the medi-
cal management of pediatric vesicoureteral reflux. Int
J Urol. 2020;27(6):480-490.
2.
Khoury AE, Bägli DJ. Vesicoureteral reflux. In:
Campbell MF, Wein AJ, Kavoussi LR editors. Camp-
bell-Walsh Urology. Philadelphia: Saunders/Elsevier,
2007.
3.
Mohanan N, Colhoun E, Puri P. Renal parenchy-
mal damage in intermediate and high grade infan-
tile vesicoureteral reflux. J Urol. 2008;180(4 Sup-
pl):1635-1638.
4.
Swerkersson S, Jodal U, Sixt R, Stokland E, Hansson
S. Relationship among vesicoureteral reflux, urinary
tract infection and renal damage in children. J Urol.
2007;178(2):647-651.
5.
Lundstedt AC, McCarthy S, Gustafsson MC, Go-
daly G, Jodal U, Karpman D, et al A genetic basis
of susceptibility to acute pyelonephritis. PLoS One.
2007;2(9):e825. Published 2007 Sep 5.
6.
Kacsó IM, Borza GM, Ciuce CC, Bîrsan A, Apostu
RC, Dindelegan GC, et al Expression of TLR4 protein
is reduced in chronic renal failure: evidence from an
experimental model of nephron reduction. Rom J
Morphol Embryol. 2015;56(1):93-99.
7.
Lebowitz RL, Olbing H, Parkkulainen KV, Smellie
JM, Tamminen-Möbius TE. International system of
radiographic grading of vesicoureteric reflux. Inter-
national Reflux Study in Children. Pediatr Radiol.
1985;15(2):105-109.
8.
Tabel Y, Berdeli A, Mir S. Association of TLR2 gene
Arg753Gln polymorphism with urinary tract infection
in children. Int J Immunogenet. 2007;34(6):399-405.
9.
Ragnarsdóttir B, Lutay N, Grönberg-Hernandez J,
Köves B, Svanborg C. Genetics of innate immunity
and UTI susceptibility. Nat Rev Urol. 2011;8(8):449-
468. Published 2011 Jul 12.
10. Ilyas M. Next-Generation Sequencing in Diagnos-
tic Pathology. Pathobiology. 2017;84(6):292-305.
doi:10.1159/000480089
11. Chowdhury P, Sacks SH, Sheerin NS. Minireview:
functions of the renal tract epithelium in coordinating
the innate immune response to infection. Kidney Int.
2004;66(4):1334-1344.
12. Akil I, Ozkinay F, Onay H, Canda E, Gumuser G,
Kavukcu S. Assessment of Toll-like receptor-4 gene
polymorphism on pyelonephritis and renal scar. Int
J Immunogenet. 2012;39(4):303-307.
13. Ragnarsdóttir B, Jönsson K, Urbano A, Grönberg-
Hernandez J, Lutay N, Tammi M, et al. Toll-like re-
ceptor 4 promoter polymorphisms: common TLR4
variants may protect against severe urinary tract
infection. PLoS One. 2010;5(5):e10734. Published
2010 May 20.
14. Netea MG, Wijmenga C, O’Neill LA. Genetic varia-
tion in Toll-like receptors and disease susceptibil-
ity. Nat Immunol. 2012;13(6):535-542. Published
2012 May 18.
15. Anders HJ, Banas B, Schlöndorff D. Signaling dan-
ger: toll-like receptors and their potential roles in
kidney disease. J Am Soc Nephrol. 2004;15(4):854-
867.
16. Ben Mkaddem S, Pedruzzi E, Werts C, Coant N, Bens
M, Cluzeaud F, et al. Heat shock protein gp96 and
NAD(P)H oxidase 4 play key roles in Toll-like receptor
4-activated apoptosis during renal ischemia/reperfu-
sion injury. Cell Death Differ. 2010;17(9):1474-1485.
17. Akira S, Takeda K, Kaisho T. Toll-like receptors:
critical proteins linking innate and acquired immu-
nity. Nat Immunol. 2001;2(8):675-680.
18. Misch EA, Hawn TR. Toll-like receptor polymor-
phisms and susceptibility to human disease. Clin Sci
(Lond). 2008;114(5):347-360.
19. Svanborg C, Frendéus B, Godaly G, Hang L, Hedlund
M, Wachtler C. Toll-like receptor signaling and che-
mokine receptor expression influence the severity of
urinary tract infection. J Infect Dis. 2001;183 Suppl
1:S61-S65.
20. Lorenz E, Mira JP, Frees KL, Schwartz DA. Rel-
evance of mutations in the TLR4 receptor in patients
with gram-negative septic shock. Arch Intern Med.
2002;162(9):1028-1032.
21. Torices S, Alvarez-Rodríguez L, Varela I, Muñoz P,
Balsa A, López-Hoyos M, et al. Evaluation of Toll-
like-receptor gene family variants as prognostic
biomarkers in rheumatoid arthritis. Immunol Lett.
2017;187:35-40.
22. Rani A, Nawaz SK, Arshad M, Irfan S. Role of
rs4986790 Polymorphism of TLR4 Gene in Suscep-
tibility towards Malaria Infection in the Pakistani
Population. Iran J Public Health. 2018;47(5):735-741.
23. Cunningham PN, Wang Y, Guo R, He G, Quigg RJ.
Role of Toll-like receptor 4 in endotoxin-induced acute
renal failure. J Immunol. 2004;172(4):2629-2635.
24. Agnese DM, Calvano JE, Hahm SJ, Coyle SM, Cor-
bett SA, Calvano SE, et al. Human toll-like recep-
tor 4 mutations but not CD14 polymorphisms are
associated with an increased risk of gram-negative
infections. J Infect Dis. 2002;186(10):1522-1525.
25. Avdonina MA, Abramov IS, Ammour YI, Nasedkina
TV. Mol Biol (Mosk). 2017;51(2):301-307.
26. Karoly E, Fekete A, Banki NF, Szebeni B, Vannay
A, Szabo AJ, et al. Heat shock protein 72 (HSPA1B)
gene polymorphism and Toll-like receptor (TLR) 4
mutation are associated with increased risk of urinary
tract infection in children [published correction ap-
pears in Pediatr Res. 2007 Oct;62(4):482]. Pediatr
Res. 2007;61(3):371-374.
27. Huang WL, Xu Y, Wan SP. Association of Toll-like 4
receptor gene polymorphism (rs4986790, rs4986791)
with the risk of urinary tract infection: A systematic
review and meta-analysis. Kaohsiung J Med Sci.
2020;36(3):206-211.
28. Allsopp LP, Wood TE, Howard SA, Maggiorelli F,
Nolan LM, Wettstadt S, et al. RsmA and AmrZ or-
chestrate the assembly of all three type VI secretion
systems in Pseudomonas aeruginosa. Proc Natl Acad
Sci U S A. 2017;114(29):7707-7712.
29. Adams T, Ennuson NAA, Quashie NB, Futagbi G,
Matrevi S, Hagan OCK, et al. Prevalence of Plas-
modium falciparum delayed clearance associated
polymorphisms in adaptor protein complex 2 mu
subunit (pfap2mu) and ubiquitin specific protease 1
(pfubp1) genes in Ghanaian isolates. Parasit Vectors.
2018;11(1):175.
30. Hnatyszyn A, Szalata M, Zielińska A, Wielgus K,
Danielewski M, Hnatyszyn PT, et al. Mutations in He-
licobacter pylori infected patients with chronic gastri-
tis, intestinal type of gastric cancer and familial gas-
tric cancer. Hered Cancer Clin Pract. 2024;22(1):9.
31. Moalem S, Keating S, Shannon P, Thompson M, Mil-
lar K, Nykamp K, et al. Broadening the ciliopathy
spectrum: motile cilia dyskinesia, and nephronophthi-
sis associated with a previously unreported homozy-
gous mutation in the INVS/NPHP2 gene. Am J Med
Genet A. 2013;161A(7):1792-1796.
32. Kaefer M, Curran M, Treves ST, Bauer S, Hendren
WH, Peters CA, et al. Sibling vesicoureteral reflux
in multiple gestation births. Pediatrics. 2000;105(4
Pt 1):800-804.
33. Noe HN, Wyatt RJ, Peeden JN Jr, Rivas ML. The
transmission of vesicoureteral reflux from parent to
child. J Urol. 1992;148(6):1869-1871.
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