Balkan Journal of Medical Genetics

INVESTIGATION OF TLR4 POLYMORPHISM IN CHILDREN WITH VESICOURETERAL REFLUX AND RENAL SCARRING
Sav NM1*, Eroz R2, Kalay Duran N3, Kilicaslan O4, Erisen Karaca S5
*Corresponding Author: *Corresponding Author: Nadide Melike SAV, Address: Duzce Universitesi Araştırma Uygulama Hastanesi, Pediatrik Nefroloji B.D, Merkez, DUZCE, TURKEY; Phone: +905378683281; Fax:+903805421390; e-mail address: savmelike@gmail.com
page: 41

RESULTS

A total of 49 individuals, 26 (53.1%) of them with kidney scars and 23 (46.9%) without scars were included in the current study. Both groups were similar in terms of age. The distribution of cases with scars was as follows: Seven (14.3%) with bilateral multiple scars, four (8.2%) with one scar on the right, eight (16.3%) with multiple scars on the right, one (2%) with multiple scars on the right and renal atrophy on the right, three (6.1%) with one scar on the left, and three (6.1%) with multiple scars on the left. The age of patients with kidney scars was found to be significantly higher than that of patients without kidney scars (p<0.001). Two groups were similar with respect to the gender distribution and the level of serum urea (p=0.786 and p=0.667, respectively). The levels of systolic and diastolic blood pressures and serum creatinine were significantly higher in patients with scars compared to those without any scar (for all, p<0.001). However, although the estimated glomerular filtration rate was lower in the group with scars, no statistically significant differ- ence was observed between the groups (p>0.05), (Table 1). The distribution of VUR severity within each group is presented in Figure 1. There was a significant differ- ence between the two groups with respect to the severity of VUR (p<0.001). The patients with grade 4 VUR were significantly more frequent in the group with scars, while the patients with grade 1 VUR were significantly more frequent in the group without any scar (p<0.05). Compound heterozygous variations were more com- mon in patients with kidney scarring (p<0.05) (Table 2). Furthermore, although not statistically significant, the variations, heterozygous c.942A>G p.Lys314 in Ex4 rs56070048, heterozygous c.896AT p.Thr399Ile rs4986791 in EX3 and heterozygous c.1078C>T p.Ser360Pro in Ex3 were found more commonly in pa- tients with scarring compared to those without scarring (p>0.05) (Table 2).

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