INVESTIGATION OF TLR4 POLYMORPHISM IN CHILDREN WITH VESICOURETERAL REFLUX AND RENAL SCARRING
Sav NM1*, Eroz R2, Kalay Duran N3, Kilicaslan O4, Erisen Karaca S5
*Corresponding Author: *Corresponding Author: Nadide Melike SAV, Address: Duzce Universitesi Araştırma Uygulama Hastanesi, Pediatrik Nefroloji B.D, Merkez, DUZCE, TURKEY; Phone: +905378683281; Fax:+903805421390; e-mail address: savmelike@gmail.com
page: 41
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CONCLUSION
It is known that TLR4 gene variations increase the
frequency of infection and consequently the susceptibility
to the development of scar tissue. This is the first study
investigating TLR4 gene variations by NGS method. Varia-
tions of c.958T>C, c.776A>G, c.1076C>T, c.896AT, c.315C>T, c.1078C>T were found at high
rates in patients with kidney scarring. Studies with many
patients are needed for revealing the effects of both genetic
and environmental factors on the development of kidney
scarring.
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