COMPARISON OF FGF -8, FGF -10, FGF- RECEPTOR 2,
ANDROGEN RECEPTOR, ESTROGEN RECEPTOR-Α
AND SS IN HEALTHY AND HYPOSPADIAC CHILDREN
Emaratpardaz N, Turkyilmaz Z, Karabulut R, Dayanir D, Kaya C, Sert AAE, Arkan G, Ucaner FA, Kapisiz A, Eryilmaz S, Atan A, Sonmez K
*Corresponding Author: Prof. Ramazan Karabulut, MD, Gazi University Faculty of Medicine,
Department of Pediatric Surgery, Besevler, 06550, Ankara-Turkey. Tel: +90 312 2026210;
Fax: +90 312 2230528. E-mail: karabulutr@yahoo.com, ramazank@gazi.edu.tr
page: 21
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Abstract
In this study, we aimed to investigate the levels of
Fibroblast Growth Factor-8 (FGF-8), FGF-10, FGF-Re-
ceptor-2 (FGFR-2), Androgen receptor (AR), Estrogen
receptor alpha and beta (ER-α and ER-ß) in the foreskins
of children with and without hypospadias.
Methods: Samples from the foreskins of 20 chil-
dren with hypospadias and 20 skin samples from children
without hypospadias between the ages of 14 months and
12 years were taken during circumcision or hypospadias
correction surgery for immunohistochemical (IHC) exami-
nation of these markers. In IHC examination, it was shown
that ER-α, ER-ß and AR receptors were more involved in
the foreskin of children with hypospadias than in the fore-
skin of without hypospadias children, and FGF-8, FGF-10
and FGFR-2 were lower (p<0.05). ER and AR uptake were
higher in hypospadias tissue samples and FGF-8, FGF-10,
and FGFR-2 uptakes were lower compared to without
hypospadias children’s tissue samples, and these factors
were supported by affecting each other in the develop-
ment of hypospadias. The limited number of studies on
this subject in the literature and the contradictory results
of the findings indicate that more research should be done
on this subject in the future.
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