
COMPARISON OF FGF -8, FGF -10, FGF- RECEPTOR 2,
ANDROGEN RECEPTOR, ESTROGEN RECEPTOR-Α
AND SS IN HEALTHY AND HYPOSPADIAC CHILDREN Emaratpardaz N, Turkyilmaz Z, Karabulut R, Dayanir D, Kaya C, Sert AAE, Arkan G, Ucaner FA, Kapisiz A, Eryilmaz S, Atan A, Sonmez K *Corresponding Author: Prof. Ramazan Karabulut, MD, Gazi University Faculty of Medicine,
Department of Pediatric Surgery, Besevler, 06550, Ankara-Turkey. Tel: +90 312 2026210;
Fax: +90 312 2230528. E-mail: karabulutr@yahoo.com, ramazank@gazi.edu.tr page: 21
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REFERENCES
1. Bouty A, Ayers KL, Pask A, Heloury Y, Sinclair AH.
The Genetic and Environmental Factors Underlying
Hypospadias. Sex Dev. 2015;9(5):239-259.
2. Blaschko SD, Cunha GR, Baskin LS. Molecular
mechanisms of external genitalia development. Dif-
ferentiation. 2012;84(3):261-268.
3. van der Horst HJ, de Wall LL. Hypospadias, all there
is to know. Eur J Pediatr. 2017;176(4):435-441.
4. George M, Schneuer FJ, Jamieson SE, Holland AJ.
Genetic and environmental factors in the aetiology of
hypospadias. Pediatr Surg Int. 2015;31(6):519-527.
5. Kalfa N, Gaspari L, Ollivier M, Philibert P, Bergoug-
noux A, Paris F, et al. Molecular genetics of hypospa-
dias and cryptorchidism recent developments. Clin
Genet. 2019;95(1):122-131.
6. Chen Z, Lei Y, Finnell RH, Ding Y, Su Z, Wang Y, et
al. Whole-exome sequencing study of hypospadias.
iScience. 2023;26(5):106663.
7. Haid B, Pechriggl E, Nägele F, Dudas J, Webersinke
G, Rammer M, et al. FGF8, FGF10 and FGF receptor
2 in foreskin of children with hypospadias: an analysis
of immunohistochemical expression patterns and gene
transcription. J Pediatr Urol. 2020;16(1):41.e1-e10.
8. Pichler R, Djedovic G, Klocker H, Heidegger I, Stra-
sak A, Loidl W, et al. Quantitative measurement of
the androgen receptor in prepuces of boys with and
without hypospadias. BJU Int. 2013;112(2):265-270.
9. Qiao L, Rodriguez E Jr, Weiss DA, Ferretti M, Ris-
bridger G, Cunha GR, et al. Expression of estrogen
receptor alpha and beta is decreased in hypospadias.
J Urol. 2012;187(4):1427-1433.
10. Khanna S, Shankar Raman V, Badwal S, Vinu Bal-
raam KV. Quantification of the Androgen and Estro-
gen Receptors in the Penile Tissues of Hypospadias
in Comparison with Normal Children. Fetal Pediatr
Pathol. 2023;42(2):175-186.
11. Kocaturk H, Özkaya F, Adanur S, Yapanoglu T, Ak-
soy Y. Expression of androgen receptor and estrogen
receptor-beta in foreskin tissue of hypospadiac and
healthy boys. Arch Esp Urol. 2020;73(2):119-125.
12. Nikolaev VV, Solontsov YN. [Epidemiology and
theories of the origin of hypospadias]. Urologiia.
2018;(3):141-145.
13. Marrocco G, Grammatico P, Vallasciani S, Gulia C,
Zangari A, Marrocco F, et al. Environmental, paren-
tal and gestational factors that influence the occur-
rence of hypospadias in male patients. J Pediatr Urol.
2015;11(1):12-19.
14. Zhou X, Zhang X, Zhou X, Abulimiti G, Wang Y,
Zhang Q, et al. Identification of endocrine-disrupting
chemicals targeting the genes and pathways of genital
anomalies in males. Ecotoxicol Environ Saf. 2022;
247:114241.
15. Cripps SM, Mattiske DM, Black JR, Risbridger GP,
Govers LC, Phillips TR, et al. A loss of estrogen sig-
naling in the aromatase deficient mouse penis results
in mild hypospadias. Differentiation. 2019;109: 42-52.
16. Do MT, Kim L, Im YJ, Hahn S, Park K. Effect of
Preoperative Androgen Stimulation on Penile Size
and Postoperative Complication Rate in Patients
with Hypospadias: A Systematic Review and Meta-
analysis. World J Mens Health. 2023; 41(3):558-574.
17. Nagaraja MR, Gubbala SP, Delphine Silvia CRW,
Amanchy R. Molecular diagnostics of disorders
of sexual development: an Indian survey and sys-
tems biology perspective. Syst Biol Reprod Med.
2019;65(2):105-120.
18. Celayir A, Moralioglu S, Cetiner H, Kir G, Celayir S.
Expression of androgen, estrogen, and progesterone
hormone receptors in the penile tissues of children
with different types of hypospadias. North Clin Is-
tanb. 2018;6(2):110-116.
19. Cunha GR, Risbridger G, Wang H, Place NJ, Grum-
bach M, Cunha TJ, et al. Development of the external
genitalia: perspectives from the spotted hyena (Cro-
cuta crocuta). Differentiation. 2014;87(1-2):4-22.
20. Joodi M, Amerizadeh F, Hassanian SM, Erfani M,
Ghayour-Mobarhan M, Ferns GA, et al. The ge-
netic factors contributing to hypospadias and their
clinical utility in its diagnosis. J Cell Physiol. 2019;
234(5):5519-5523.
21. Lorenzi MV, Long JE, Miki T, Aaronson SA. Expres-
sion cloning, developmental expression and chro-
mosomal localization of fibroblast growth factor-8.
Oncogene. 1995;10(10):2051-2055.
22. Gnanapragasam VJ, Robson CN, Neal DE, Leung
HY. Regulation of FGF8 expression by the andro-
gen receptor in human prostate cancer. Oncogene.
2002;21(33):5069-5080.
23. Gredler ML, Seifert AW, Cohn MJ. Tissue-specific
roles of FGFR-2 in development of the external geni-
talia. Development. 2015;142(12):2203-2212.
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