COMPARISON OF FGF -8, FGF -10, FGF- RECEPTOR 2,
ANDROGEN RECEPTOR, ESTROGEN RECEPTOR-Α
AND SS IN HEALTHY AND HYPOSPADIAC CHILDREN
Emaratpardaz N, Turkyilmaz Z, Karabulut R, Dayanir D, Kaya C, Sert AAE, Arkan G, Ucaner FA, Kapisiz A, Eryilmaz S, Atan A, Sonmez K
*Corresponding Author: Prof. Ramazan Karabulut, MD, Gazi University Faculty of Medicine,
Department of Pediatric Surgery, Besevler, 06550, Ankara-Turkey. Tel: +90 312 2026210;
Fax: +90 312 2230528. E-mail: karabulutr@yahoo.com, ramazank@gazi.edu.tr
page: 21
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CONCLUSIONS
IHC studies on the foreskin of children with hypo-
spadias and without hypospadias revealed that ER and AR
uptake were higher in hypospadias tissue samples, also
that FGF-8, FGF-10, and FGFR-2 uptakes were lower
compared to the children’s tissue samples who did not
have hypospadias. These factors were supported by af-
fecting each other in the development of hypospadias.
There are not many studies on this topic in the literature,
and the conflicting results for some of the analyzed criteria
suggest that further study on this topic needs to be done
in the future.
Funding
This study was sponsored by the Scientific Research
Foundation of Gazi University (9/2022-7828).
Authors’ Contribution
NE, ZT, RK, AA and KS performed to study con-
ception and design. NE, GA and FAU performed data
acquisition. DD, AAMS, NE and RK performed analysis
and data interpretation. ZT, RK and KS read and re-written
the article. KS and AA were involved in revision of the
article and mentorship throughout. All authors read and
approved the final version of the manuscript
Ethical approval and consent to participate
The study (07/03/2022-191) began with approval
from the Gazi University Ethical Committee. In confor-
mity with the Helsinki Declaration, all procedures were
carried out.
Competing interests
None declared.
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