CYTOGENETIC ABNORMALITIES IN ACUTE LEUKEMIA PATIENTS: RESULTS OF CONVENTIONAL CYTOGENETICS AND FLUORESCENT IN SITU HYBRIDIZATION ANALYSES
Yilmaz Z1,*, Sahin FI1, Kizilkilic E2, Karakus S3, ?zbek N4, Boga C2, ?zdogu H2
*Corresponding Author: Zerrin Yilmaz, MD, Baskent University Faculty of Medicine, Department of Medical Biology and Genetics, Kubilay Sokak No. 36, 06570 Maltepe, Ankara, Turkey; Tel.: +90-312-232-44-00/139; Fax: +90-312-232-39-12; E-mail: zerriny@baskent.edu.tr
page: 33

INTRODUCTION

Acute leukemia arises from clonal expansion of a progenitor cell. The underlying mechanism has been reported to be the presence of cytogenetic aberrations [1]. Cytogenetic analysis of hematological malignancies has been proved to be important in the diagnosis and treatment of leukemia [2]. Disease-specific chromosomal aberrations are associated with the leukemia type. The chromosomal abnormalities have been analyzed at the molecular level, and structurally rearranged and deregulated genes have been identified [3]. Conventional G-banding analysis of chromosomes is not sensitive enough to detect chromosomal aberrations, especially after chemotherapy and during remission [3]. A correlation between fluorescent in situ hybridization (FISH) and G-banding results has been previously reported for some chromosomal aberrations [3]. There is a lack of correlation in other rearrangements but interphase FISH overcomes the difficulties of conventional cytogenetics in these particular situations [3]. Our purpose in this study was to detect and compare chromosome rearrangements in acute leukemia patients by conventional cytogenetics and FISH methods.

 




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