CYTOGENETIC ABNORMALITIES IN ACUTE LEUKEMIA PATIENTS: RESULTS OF CONVENTIONAL CYTOGENETICS AND FLUORESCENT IN SITU HYBRIDIZATION ANALYSES
Yilmaz Z1,*, Sahin FI1, Kizilkilic E2, Karakus S3, ?zbek N4, Boga C2, ?zdogu H2
*Corresponding Author: Zerrin Yilmaz, MD, Baskent University Faculty of Medicine, Department of Medical Biology and Genetics, Kubilay Sokak No. 36, 06570 Maltepe, Ankara, Turkey; Tel.: +90-312-232-44-00/139; Fax: +90-312-232-39-12; E-mail: zerriny@baskent.edu.tr
page: 33

Abstract

 Acute leukemia is classified as acute lymphoblastic leukemia (ALL) or acute myeloblastic leukemia (AML), according to the type of the progenitor cell from which the disease originates Chromosome rearrangements play a crucial role in the pathogenesis, and conventional cyto?genetics has a primary importance in diagnosis of patients. More sensitive methods, such as fluorescent in situ hybridization (FISH), are recommended to reveal cryptic rearrangements or when karyotype analysis is not possible because of poor chromosome quality. In this study, we compared the results of conventional cytogenetics and FISH in 71 acute leukemia patients. In 28 patients, we detected chromosome rearrangements either by conventional cytogenetics or by FISH. In 15 patients, conventional cytogenetics revealed a normal karyotype, whereas FISH revealed the rearrangements. In two patients, conventional cytogenetics results were not available. In these cases, FISH enabled detection of t(9;22). As a result, we concluded that both methods need to be performed at initial diagnosis, so as to guide the treatment and follow-up of patients.

Key words: Acute lymphoblastic leukemia (ALL); Acute myeloblastic leukemia (AML); inversion 16; MLL; t(9;22); t(15;17).

 




Number 20
VOL. 20 (1), 2017
Number 19
VOL. 19 (2), 2016
Number 19
VOL. 19 (1), 2016
Number 18
VOL. 18 (2), 2015
Number 18
VOL. 18 (1), 2015
Number 17
VOL. 17 (2), 2014
Number 17
VOL. 17 (1), 2014
Number 16
VOL. 16 (2), 2013
Number 16
VOL. 16 (1), 2013
Number 15
VOL. 15 (2), 2012
Number 15
VOL. 15, 2012 Supplement
Number 15
Vol. 15 (1), 2012
Number 14
14 - Vol. 14 (2), 2011
Number 14
The 9th Balkan Congress of Medical Genetics
Number 14
14 - Vol. 14 (1), 2011
Number 13
Vol. 13 (2), 2010
Number 13
Vol.13 (1), 2010
Number 12
Vol.12 (2), 2009
Number 12
Vol.12 (1), 2009
Number 11
Vol.11 (2),2008
Number 11
Vol.11 (1),2008
Number 10
Vol.10 (2), 2007
Number 10
10 (1),2007
Number 9
1&2, 2006
Number 9
3&4, 2006
Number 8
1&2, 2005
Number 8
3&4, 2004
Number 7
1&2, 2004
Number 6
3&4, 2003
Number 6
1&2, 2003
Number 5
3&4, 2002
Number 5
1&2, 2002
Number 4
Vol.3 (4), 2000
Number 4
Vol.2 (4), 1999
Number 4
Vol.1 (4), 1998
Number 4
3&4, 2001
Number 4
1&2, 2001
Number 3
Vol.3 (3), 2000
Number 3
Vol.2 (3), 1999
Number 3
Vol.1 (3), 1998
Number 2
Vol.3(2), 2000
Number 2
Vol.1 (2), 1998
Number 2
Vol.2 (2), 1999
Number 1
Vol.3 (1), 2000
Number 1
Vol.2 (1), 1999
Number 1
Vol.1 (1), 1998

 

 


 About the journal ::: Editorial ::: Subscription ::: Information for authors ::: Contact
 Copyright © Balkan Journal of Medical Genetics 2006