CYTOGENETIC ABNORMALITIES IN ACUTE LEUKEMIA
PATIENTS: RESULTS OF CONVENTIONAL CYTOGENETICS
AND FLUORESCENT IN SITU HYBRIDIZATION ANALYSES
Yilmaz Z1,*, Sahin FI1, Kizilkilic E2, Karakus S3, ?zbek N4, Boga C2, ?zdogu H2
*Corresponding Author: Zerrin Yilmaz, MD, Baskent University Faculty of Medicine, Department of Medical Biology and Genetics, Kubilay Sokak No. 36, 06570 Maltepe, Ankara, Turkey; Tel.: +90-312-232-44-00/139; Fax: +90-312-232-39-12; E-mail: zerriny@baskent.edu.tr
page: 33
|
Abstract
Acute leukemia is classified as acute lymphoblastic leukemia (ALL) or acute myeloblastic leukemia (AML), according to the type of the progenitor cell from which the disease originates Chromosome rearrangements play a crucial role in the pathogenesis, and conventional cyto?genetics has a primary importance in diagnosis of patients. More sensitive methods, such as fluorescent in situ hybridization (FISH), are recommended to reveal cryptic rearrangements or when karyotype analysis is not possible because of poor chromosome quality. In this study, we compared the results of conventional cytogenetics and FISH in 71 acute leukemia patients. In 28 patients, we detected chromosome rearrangements either by conventional cytogenetics or by FISH. In 15 patients, conventional cytogenetics revealed a normal karyotype, whereas FISH revealed the rearrangements. In two patients, conventional cytogenetics results were not available. In these cases, FISH enabled detection of t(9;22). As a result, we concluded that both methods need to be performed at initial diagnosis, so as to guide the treatment and follow-up of patients.
Key words: Acute lymphoblastic leukemia (ALL); Acute myeloblastic leukemia (AML); inversion 16; MLL; t(9;22); t(15;17).
|
|
|
|
|
Number 26 Number 26 VOL. 26(2), 2023 All in one |
Number 26 VOL. 26(2), 2023 |
Number 26 VOL. 26, 2023 Supplement |
Number 26 VOL. 26(1), 2023 |
Number 25 VOL. 25(2), 2022 |
Number 25 VOL. 25 (1), 2022 |
Number 24 VOL. 24(2), 2021 |
Number 24 VOL. 24(1), 2021 |
Number 23 VOL. 23(2), 2020 |
Number 22 VOL. 22(2), 2019 |
Number 22 VOL. 22(1), 2019 |
Number 22 VOL. 22, 2019 Supplement |
Number 21 VOL. 21(2), 2018 |
Number 21 VOL. 21 (1), 2018 |
Number 21 VOL. 21, 2018 Supplement |
Number 20 VOL. 20 (2), 2017 |
Number 20 VOL. 20 (1), 2017 |
Number 19 VOL. 19 (2), 2016 |
Number 19 VOL. 19 (1), 2016 |
Number 18 VOL. 18 (2), 2015 |
Number 18 VOL. 18 (1), 2015 |
Number 17 VOL. 17 (2), 2014 |
Number 17 VOL. 17 (1), 2014 |
Number 16 VOL. 16 (2), 2013 |
Number 16 VOL. 16 (1), 2013 |
Number 15 VOL. 15 (2), 2012 |
Number 15 VOL. 15, 2012 Supplement |
Number 15 Vol. 15 (1), 2012 |
Number 14 14 - Vol. 14 (2), 2011 |
Number 14 The 9th Balkan Congress of Medical Genetics |
Number 14 14 - Vol. 14 (1), 2011 |
Number 13 Vol. 13 (2), 2010 |
Number 13 Vol.13 (1), 2010 |
Number 12 Vol.12 (2), 2009 |
Number 12 Vol.12 (1), 2009 |
Number 11 Vol.11 (2),2008 |
Number 11 Vol.11 (1),2008 |
Number 10 Vol.10 (2), 2007 |
Number 10 10 (1),2007 |
Number 9 1&2, 2006 |
Number 9 3&4, 2006 |
Number 8 1&2, 2005 |
Number 8 3&4, 2004 |
Number 7 1&2, 2004 |
Number 6 3&4, 2003 |
Number 6 1&2, 2003 |
Number 5 3&4, 2002 |
Number 5 1&2, 2002 |
Number 4 Vol.3 (4), 2000 |
Number 4 Vol.2 (4), 1999 |
Number 4 Vol.1 (4), 1998 |
Number 4 3&4, 2001 |
Number 4 1&2, 2001 |
Number 3 Vol.3 (3), 2000 |
Number 3 Vol.2 (3), 1999 |
Number 3 Vol.1 (3), 1998 |
Number 2 Vol.3(2), 2000 |
Number 2 Vol.1 (2), 1998 |
Number 2 Vol.2 (2), 1999 |
Number 1 Vol.3 (1), 2000 |
Number 1 Vol.2 (1), 1999 |
Number 1 Vol.1 (1), 1998 |
|
|