DETERMINATION OF THE RELATIONSHIP BETWEEN DNA METHYLATION STATUS OF KLOTHO AND ARNTL GENES WITH HYPERTENSION
Osum M, Tosun O, Birtan H, Kalkan R
*Corresponding Author: Prof. Dr.Rasime Kalkan, PhD, Faculty of Medicine, European University of Lefke, Mersin 10, Lefke 99728, Northern Cyprus, Turkey, kalkanr@yahoo.com, rkalkan@eul.edu.tr
page: 41
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CONCLUSION
Several studies have revealed the influence of KL
and ARNTL polymorphisms and altered gene expression
on hypertensive patients. Considering these results we
focused in this study on understanding the importance
of the methylation status of these genes in hypertension
and their interaction with biochemical parameters. Although we could not detect a significant difference in KL
and ARNTL methylation status in hypertension patients
and controls, this study will shed light on the analysis
and determination of new epigenetic pathways involving
KL and ARNTL genes. Furthermore, except for ARNTL,
considering that other core circadian clock genes may
participate in the onset and progression of hypertension,
their epigenetic analysis may provide further information
on the determination of the mechanisms involved in the
hypertension progress.
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