Balkan Journal of Medical Genetics

DETERMINATION OF THE RELATIONSHIP BETWEEN DNA METHYLATION STATUS OF KLOTHO AND ARNTL GENES WITH HYPERTENSION
Osum M, Tosun O, Birtan H, Kalkan R
*Corresponding Author: Prof. Dr.Rasime Kalkan, PhD, Faculty of Medicine, European University of Lefke, Mersin 10, Lefke 99728, Northern Cyprus, Turkey, kalkanr@yahoo.com, rkalkan@eul.edu.tr
page: 41

RESULTS

The mean age of 76 patients who suffered from hy- pertension is 60.04 ± 13.57 years old, while the control subjects were at 44.45 ± 13.94 years old (n=49). Promoter methylation status of KLOTHO and ARNTL in hypertensive and control subjects A comparison of the methylation status of KLOTHO and ARNTL in hypertensive and control subjects was shown in Table 1. A total of 46 of the 67 methylated ARNTL subjects were hypertensive (68.7%) while 27 of the 48 unmethylated ARNTL subjects were hypertensive individuals (56.2%). The association between the methylation status of the ARNTL gene and hypertension was not significant (p > 0.05) (Table 1 and Figure 1-2). A total of 62 of the 100 methylated KLOTHO subjects were hypertensive (62.0%). On the other hand, 16 of the 27 unmethylated KLOTHO subjects were hypertensive (59.3%). Likewise, for the ARNTL gene, the association between the methylation status of the KLOTHO gene and hypertension was not significant (p > 0.05) (Table 1 and Figure 3). The difference in metabolic characteristics between methylation levels of the KLOTHO and ARNTL genes The mean values of biochemical parameters for KLOTHO and ARNTL genes regarding the methylation status were shown in Table 2 and Table 3, respectively. The difference between the methylation status cat- egories of KLOTHO and ARNTL genes for age, glucose, triglyceride, total cholesterol, HDL-C, and LDL-C levels in blood circulation, Na, K, Cr, Urea were investigated in this study. The results indicate no statistically significant difference for age, glucose, triglyceride, total cholesterol, HDL-C, and LDL-C levels in blood circulation, Na, K, Cr, Urea for both genes (p > 0.05). A statistically significant difference was detected be- tween the methylated KLOTHO hypertensive patients and unmethylated KLOTHO control subjects for potassium (K) (p= 0,0014) (Figure 4). The Association Between ARNTL and KLOTHO Methylation Status ARNTL and KLOTHO were both methylated in 53 out of 115 subjects (46.1%) and unmethylated in 10 out of the 115 subjects (8.8%) (Table 4). The association between methylation status of KLOTHO and ARNTL genes was not statistically significant (p > 0.05).

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