DETERMINATION OF THE RELATIONSHIP BETWEEN DNA METHYLATION STATUS OF KLOTHO AND ARNTL GENES WITH HYPERTENSION
Osum M, Tosun O, Birtan H, Kalkan R
*Corresponding Author: Prof. Dr.Rasime Kalkan, PhD, Faculty of Medicine, European University of Lefke, Mersin 10, Lefke 99728, Northern Cyprus, Turkey, kalkanr@yahoo.com, rkalkan@eul.edu.tr
page: 41
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Abstract
Hypertension is a multifactorial chronic disease due to
the interaction of environmental factors with genetic altera-
tion. KLOTHO and ARNTL genes play an important role in
the development of hypertension. Therefore, we analyzed
the methylation status of KLOTHO and ARNTL genes by
using methylation-sensitive high-resolution melting (MS-
HRM) in a total of 78 hypertensive and 49 control subjects.
In this study, we could not identify a significant association
between KLOTHO and ARNTL methylation and the hyper-
tensive phenotype. Moreover, we could not find a direct
association between KLOTHO and ARNTL methylation
and the fasting blood sugar, triglycerides, total cholesterol,
LDL-cholesterol, HDL-cholesterol, sodium (Na), creatinine
(Cr), potassium (K), and urea levels in hypertensive patients.
However, we found a significant difference between the
methylated KLOTHO hypertensive patients and the un-
methylated KLOTHO control subjects for potassium (K).
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