DIFFERENTIALLY EXPRESSED CIRCULATING LONG-NONCODING RNAS IN PREMATURE INFANTS WITH RESPIRATORY DISTRESS SYNDROME
Bao ZD, Wan J, Zhu W, Shen JX, Yang Y, Zhou XY
*Corresponding Author: Dr. Yang Yang and Dr. Zhou Xiao‑Yu, E‑mail: yy860507@126.com (YY) and xyzhou161@163.com (XYZ), Tel:+ 86-25-83117362, Department of Neonatology, Children’s Hospital of Nanjing Medical University, Nanjing, Jiangsu 210008, P.R. China
page: 11
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CONCLUSION
135 lncRNAs were differentially expressed among
non-RDS group, mild RDS group and severe RDS group.
LncRNA-mRNA co-expression networks further identified
a total of 278 mRNAs that were closely related
to the above differentially expressed lncRNAs. Among
them, the differential expression of ENST00000470527.1,
ENST00000504497.1, ENST00000417781.5, and
ENST00000440408.5 were confirmed by qRT-PCR. The
above results could provide a new sight for researching the
potential pathophysiological mechanisms of RDS.
Funding
The present study was supported by the Maternal
and Child Health Research Project of the Wuxi Municipal
Health Commission (FYKY202007).
Authors’ contributions
YY and XYZ designed the study. ZDB, WZ, and JW
performed the experiments. ZDB, WZ, and JXS analyzed the
data. ZDB and YY drafted the manuscript. JW revised the manuscript.
All authors read and approved the final manuscript.
Ethics approval and consent to participate
All the procedures were followed in accordance with
the Declaration of Helsinki. This study was approved by the
Ethics Committee of Jiangyin People’s Hospital of Nantong
University [approval No. [(2019)011], and all the guardians
of the patients have provided written informed consent.
Conflict of interest
The authors declare no competing interests.
Acknowledgment
We are grateful for the parents’ understanding and
support.
Availability of data and materials
The dataset used during this study is available from
the corresponding author upon reasonable request.
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