Balkan Journal of Medical Genetics

DIFFERENTIALLY EXPRESSED CIRCULATING LONG-NONCODING RNAS IN PREMATURE INFANTS WITH RESPIRATORY DISTRESS SYNDROME
Bao ZD, Wan J, Zhu W, Shen JX, Yang Y, Zhou XY
*Corresponding Author: Dr. Yang Yang and Dr. Zhou Xiao‑Yu, E‑mail: yy860507@126.com (YY) and xyzhou161@163.com (XYZ), Tel:+ 86-25-83117362, Department of Neonatology, Children’s Hospital of Nanjing Medical University, Nanjing, Jiangsu 210008, P.R. China
page: 11

INTRODUCTION

Preterm respiratory distress syndrome (RDS), characterized by immature lung development, has been a severe problem for preterm infants [1]. Effective treatments include pulmonary surfactant (PS) replacement and lung-protective ventilatory strategies that could improve oxygenation and minimize ventilator-induced lung injury [2]. Recent studies have shown that normal or abnormal lung development is highly regulated by various signal molecules, including fibroblast growth factor (FGF), bone morphogenetic protein-4 (BMP‑4), transforming growth factor-beta (TGF‑β), etc. [2-3]. Long non-coding RNAs (lncRNAs) could modulate gene expression at the post-transcription level by depredating or translating target mRNAs [4]. So far, lncRNAs, characterized by a length longer than 200 nucleotides, have been demonstrated to participate in lung development and related diseases [5]. The specific expression patterns of lncRNAs have been explored in fetal lung development. Among distinct embryonic periods of lung development, a total of 687 differentially expressed lncRNAs were identified in our previous study [6]. In addition, Herriges et al. further reported that LL18/NANCI (Nkx2.1-associated noncoding intergenic RNA) and LL34 play important roles in lung development by controlling the expression of developmental transcription factors and pathways [7]. Previous studies have indicated that the components of peripheral cord blood are important clues for the identification of neonatal diseases [8]. For example, in our previous study [5 cases in neonatal acute respiratory distress syndrome (NARDS) group and 5 cases in non-NARDS group], circRNA expression profiles, in which 741 circRNAs were downregulated and 588 were upregulated, were screened with circRNA high-throughput sequencing [9]. However, the detailed molecular regulatory mechanism still remains unclear. Further exploring the role of RNAs is still important to the field of medical research. To date, few studies have investigated the role of circulating lncRNAs in RDS infants. Therefore, we planned to analyze the expression of plasma lncRNAs by RNA-sequencing and real-time quantitative PCR, then explored the potential function of differentially expressed lncRNAs by Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) in RDS infants. This research could add more useful evidence to the further study of RDS.

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