Balkan Journal of Medical Genetics

THE PREDISPOSITION FOR TYPE 2 DIABETES MELLITUS AND METABOLIC SYNDROME
Zenoaga-Barbăroșie C, Berca L, Vassu-Dimov T, Toma M, Nica MI, Alexiu-Toma OA, Ciornei C, Albu A, Nica S, Nistor C, Nica R
*Corresponding Author: Corresponding Author: Ass. Prof. Silvia Nica MD, PhD, Bucharest Emergency University Hospital, Splaiul Independentei Street, no 169, 5 District, Bucharest, Romania, 050098 Tel.: +40-21-31880500, email: silvia.nica@umfcd.ro
page: 21

RESULTS

The clinical data of subjects enrolled in the study are shown in Table 1. MetS patients have 3 (64%), 4 (32%) or 5 (4%) NCEP ATP III criteria for diagnosis. We found that T2DM was diagnosed at an earlier age compared to MetS (p=0.0003). The statistical significance of difference was greater when comparing patients who are carriers of OXTR G (54.04 vs 56.05 years old, p=0.0002) or both OXTR G and eNOS b alleles (54.00 vs 56.05, p=0.00016). Our results showed that the SOD1 AA genotype (p=0.0006) and the presence of both ACE I and OXTR A alleles (p=0.0005) are protective factors for T2DM. T2DM patients with lower triglyceride levels (<150 mg/dl) were more frequent carriers of SOD1 AA and AC genotypes when compared to HC subjects (p=0.0002 and p=0.0005, respectively). Similarly, SOD1 AA and AC genotypes were more frequent in T2DM patients with HDL levels over 40 mg/dl when comparing to HC (p=0.0002 and p=0.0004, respectively). Hypertensive T2DM patients were more frequent carriers of ACE DD genotype than HC (56.76% vs 25.83%, p=0.0005) (Table 3). In addition, this genotype, in association with eNOS bb or OXTR G, was found more frequently in alcohol consumers compared to those without this habit (p<0.0001) (Table 3). No other statistically significant associations were found between the investigated groups or subgroups of subjects.

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