THE PREDISPOSITION FOR TYPE 2 DIABETES MELLITUS AND METABOLIC SYNDROME
Zenoaga-Barbăroșie C, Berca L, Vassu-Dimov T, Toma M, Nica MI, Alexiu-Toma OA, Ciornei C, Albu A, Nica S, Nistor C, Nica R
*Corresponding Author: Corresponding Author: Ass. Prof. Silvia Nica MD, PhD, Bucharest Emergency University Hospital, Splaiul Independentei Street, no 169, 5 District, Bucharest, Romania, 050098 Tel.: +40-21-31880500, email: silvia.nica@umfcd.ro
page: 21
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Abstract
Type 2 diabetes mellitus (T2DM) and metabolic syndrome
(MetS) are diseases caused by the interaction of
genetic and non-genetic factors. Therefore, the aim of our
study was to investigate the association between six common
genetic polymorphisms and T2DM and MetS in males.
A total of 120 T2DM, 75 MetS, and 120 healthy controls
(HC) were included in the study. ACE ID, eNOS 4a/b, ATR1
A1166C, OXTR (A>G), SOD1 +35A/C, CAT-21A/T gene
polymorphisms were genotyped by PCR or PCR-RFLP
techniques. T2DM was diagnosed at an earlier age compared
to MetS (54 vs 55 years old, p=0.0003) and the difference
was greater in carriers of the OXTR G allele (54 vs
56 years old, p=0.0002) or both OXTR G and eNOS b alleles
(54 vs 56, p=0.00016). The SOD1 AA genotype (O.R.=0.11,
p=0.0006) and the presence of both ACE I and OXTR1 A
(O.R.=0.39, p=0.0005) alleles revealed to be protective for
T2DM. SOD1 AA and AC genotypes were protective factors
for triglyceride (p=0.0002 and p=0.0005, respectively) and
HDL cholesterol (p=0.0002 and p=0.0004, respectively)
levels in T2DM patients. ACE DD was identified more
frequently in hypertensive T2DM patients (O.R.=3.77,
p=0.0005) and in those who reported drinking alcohol
(p=0.0001) comparing to HC and T2DM patients who did
not drink alcohol, respectively. We observed that T2DM
patients who reported drinking alcohol had an increased
frequency of ACE DD and eNOS bb (p<0.0001), or ACE
DD and OXTR G (p<0.0001) compared to non-drinkers. No
gene polymorphisms were associated with MetS.
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