MIR-147B REGULATED PROLIFERATION AND APOPTOSIS OF GASTRIC CANCER CELLS BY TARGETING CPEB2 VIA THE PTEN PATHWAY
Tao K.1,2, Dong J-H.2, Wang D.1, Li F.2†#, Zhang Z-T.#1*
*Corresponding Author: Zhong-Tao Zhang, MD, Email: sxzhangzhongtao@sina.com, ORCID ID: 0000-0002-1184-2591 #: Zhong-Tao Zhang and Feng Li contributed equally to the article †: Co-corresponding author: Feng Li, Email: sxlifengwobuxin@sina.com, ORCID: 0000-0002-7322-422X
page: 10

REFERENCES

1. Li J, Ye D, Shen P, et al. Mir-20a-5p induced WTX deficiency promotes gastric cancer progressions through regulating PI3K/AKT signaling pathway. J Exp Clin Cancer Res. 2020; 39(1). doi: 10.1186/s13046-020- 01718-4 2. Necula L, Matei L, Dragu D, et al. Recent advances in gastric cancer early diagnosis. World J Gastroenterol. 2019; 25(17): 2029-2044. doi: 10.3748/wjg. v25.i17.2029 3. Yang W, Raufi A, Klempner SJ. Targeted therapy for gastric cancer: Molecular pathways and ongoing investigations. Biochim Biophys Acta - Rev Cancer. 2014; 1846(1): 232-237. doi: 10.1016/j.bbcan.2014.05.003 4. Wu H, Liu B, Chen Z, Li G, Zhang Z. MSC-induced lncRNA HCP5 drove fatty acid oxidation through miR-3619-5p/AMPK/PGC1α/CEBPB axis to promote stemness and chemo-resistance of gastric cancer. Cell Death Dis. 2020; 11(4). doi: 10.1038/ s41419-020-2426-z 5. Huang S, Guo Y, Li Z, et al. A systematic review of metabolomic profiling of gastric cancer and esophageal cancer. Cancer Biol Med. 2020; 17(1): 181-198. doi:10.20892/j.issn.2095-3941.2019.0348 6. Zhong BZ, Wang Q, Liu F, He JL, Xiong Y, Cao J. Effects of miR-384 and miR-134-5p acting on YY1 signaling transduction on biological function of gastric cancer cells. Onco Targets Ther. 2020; 13: 9631- 9641. doi: 10.2147/OTT.S259988 7. Kipkeeva F, Muzaffarova T, Korotaeva A, et al. MicroRNA in gastric cancer development: Mechanisms and biomarkers. Diagnostics. 2020; 10(11). doi: 10.3390/diagnostics10110891 8. Shen J, Niu W, Zhang H, Jun M, Zhang H. Downregulation of MicroRNA-147 inhibits cell proliferation and increases the chemosensitivity of gastric cancer cells to 5-Fluorouracil by directly targeting PTEN. Oncol Res. 2018; 26(6): 901-911. doi: 10.3727/096 504017X15061902533715 9. Ning X, Wang C, Zhang M, Wang K. Ectopic expression of miR-147 inhibits stem cell marker and epithelial–mesenchymal transition (EMT)-related protein expression in colon cancer cells. Oncol Res. 2019; 27(4): 399-406. doi: 10.3727/096504018X15 179675206495 10. Calin GA, Sevignani C, Dumitru CD, et al. Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers. Proc Natl Acad Sci U S A. 2004; 101(9): 2999-3004. doi: 10.1073/pnas.0307323101 11. Garzon R, Fabbri M, Cimmino A, Calin GA, Croce CM. MicroRNA expression and function in cancer. Trends Mol Med. 2006; 12(12): 580-587. doi: 10.1016/j.molmed.2006.10.006 12. Fuziwara CS, Kimura ET. MicroRNAs in thyroid development, function and tumorigenesis. Mol Cell Endocrinol. 2017; 456: 44-50. doi: 10.1016/j. mce.2016.12.017 13. Lima CR, Gomes CC, Santos MF. Role of microRNAs in endocrine cancer metastasis. Mol Cell Endocrinol. 2017; 456: 62-75. doi: 10.1016/j.mce.2017.03.015 14. Forte S, La Rosa C, Pecce V, Rosignolo F, Memeo L. The role of MicroRNAs in thyroid carcinomas. Anticancer Res. 2015; 35(4): 2037-2048. 15. Hu Y, Wang H, Chen E, Xu Z, Chen B, Lu G. Candidate microRNAs as biomarkers of thyroid carcinoma: a systematic review, meta-analysis, and experimental validation. Cancer Med. 2016; 5(9): 2602-2614. doi: 10.1002/cam4.811 16. Kleemann M, Bereuther J, Fischer S, et al. Investigation on tissue specific effects of pro-apoptotic micro RNAs revealed miR-147b as a potential biomarker in ovarian cancer prognosis. Oncotarget. 2017; 8(12): 18773-18791. doi: 10.18632/oncotarget.13095 17. Zhang E, Liu Q, Wang Y, et al. MicroRNA miR-147b promotes tumor growth via targeting UBE2N in hepatocellular carcinoma. Oncotarget. 2017; 8(69): 114072-114080. doi: 10.18632/oncotarget.23120 18. Cui S, Yang X, Zhang L, Zhao Y, Yan W. LncRNA MAFG-AS1 promotes the progression of colorectal cancer by sponging miR-147b and activation of NDUFA4. Biochem Biophys Res Commun. 2018; 506(1): 251-258. doi:10.1016/j.bbrc.2018.10.112 19. Gaedcke J, Grade M, Camps J, et al. The rectal cancer microRNAome - MicroRNA expression in rectal cancer and matched normal mucosa. Clin Cancer Res. 2012; 18(18): 4919-4930. doi: 10.1158/1078-0432. CCR-12-0016 20. Yi L, Zhong X, Chen Z, et al. MicroRNA-147b Promotes Proliferation and Invasion of Human Colorectal Cancer by Targeting RAS Oncogene Family (RAP2B). Pathobiology. 2019; 86(4): 173-181. doi: 10.1159/000495253 21. Zhu S, Wu H, Wu F, Nie D, Sheng S, Mo YY. MicroRNA- 21 targets tumor suppressor genes in invasion and metastasis. Cell Res. 2008; 18(3): 350-359. doi: 10.1038/cr.2008.24 22. Ji Z, Ju YL, Pan Z, Jiang B, Tian B. Progressive lengthening of 3′ untranslated regions of mRNAs by alternative polyadenylation during mouse embryonic development. Proc Natl Acad Sci U S A. 2009; 106(23): 9535. doi: 10.1073/pnas.0904454106 23. Morgan M, Iaconcig A, Muro AF. CPEB2, CPEB3 and CPEB4 are coordinately regulated by miRNAs recognizing conserved binding sites in paralog positions of their 3′-UTRs. Nucleic Acids Res. 2010; 38(21):7698-7710. doi:10.1093/nar/gkq635 24. Theis M, Si K, Kandel ER. Two previously undescribed members of the mouse CPEB family of genes and their inducible expression in the principal cell layers of the hippocampus. Proc Natl Acad Sci U S A. 2003; 100(16):9602-9607. doi:10.1073/ pnas.1133424100



Number 26
Number 26 VOL. 26(2), 2023 All in one
Number 26
VOL. 26(2), 2023
Number 26
VOL. 26, 2023 Supplement
Number 26
VOL. 26(1), 2023
Number 25
VOL. 25(2), 2022
Number 25
VOL. 25 (1), 2022
Number 24
VOL. 24(2), 2021
Number 24
VOL. 24(1), 2021
Number 23
VOL. 23(2), 2020
Number 22
VOL. 22(2), 2019
Number 22
VOL. 22(1), 2019
Number 22
VOL. 22, 2019 Supplement
Number 21
VOL. 21(2), 2018
Number 21
VOL. 21 (1), 2018
Number 21
VOL. 21, 2018 Supplement
Number 20
VOL. 20 (2), 2017
Number 20
VOL. 20 (1), 2017
Number 19
VOL. 19 (2), 2016
Number 19
VOL. 19 (1), 2016
Number 18
VOL. 18 (2), 2015
Number 18
VOL. 18 (1), 2015
Number 17
VOL. 17 (2), 2014
Number 17
VOL. 17 (1), 2014
Number 16
VOL. 16 (2), 2013
Number 16
VOL. 16 (1), 2013
Number 15
VOL. 15 (2), 2012
Number 15
VOL. 15, 2012 Supplement
Number 15
Vol. 15 (1), 2012
Number 14
14 - Vol. 14 (2), 2011
Number 14
The 9th Balkan Congress of Medical Genetics
Number 14
14 - Vol. 14 (1), 2011
Number 13
Vol. 13 (2), 2010
Number 13
Vol.13 (1), 2010
Number 12
Vol.12 (2), 2009
Number 12
Vol.12 (1), 2009
Number 11
Vol.11 (2),2008
Number 11
Vol.11 (1),2008
Number 10
Vol.10 (2), 2007
Number 10
10 (1),2007
Number 9
1&2, 2006
Number 9
3&4, 2006
Number 8
1&2, 2005
Number 8
3&4, 2004
Number 7
1&2, 2004
Number 6
3&4, 2003
Number 6
1&2, 2003
Number 5
3&4, 2002
Number 5
1&2, 2002
Number 4
Vol.3 (4), 2000
Number 4
Vol.2 (4), 1999
Number 4
Vol.1 (4), 1998
Number 4
3&4, 2001
Number 4
1&2, 2001
Number 3
Vol.3 (3), 2000
Number 3
Vol.2 (3), 1999
Number 3
Vol.1 (3), 1998
Number 2
Vol.3(2), 2000
Number 2
Vol.1 (2), 1998
Number 2
Vol.2 (2), 1999
Number 1
Vol.3 (1), 2000
Number 1
Vol.2 (1), 1999
Number 1
Vol.1 (1), 1998

 

 


 About the journal ::: Editorial ::: Subscription ::: Information for authors ::: Contact
 Copyright © Balkan Journal of Medical Genetics 2006