MIR-147B REGULATED PROLIFERATION AND APOPTOSIS OF GASTRIC CANCER CELLS BY TARGETING CPEB2 VIA THE PTEN PATHWAY
Tao K.1,2, Dong J-H.2, Wang D.1, Li F.2#, Zhang Z-T.#1*
*Corresponding Author: Zhong-Tao Zhang, MD, Email: sxzhangzhongtao@sina.com, ORCID ID: 0000-0002-1184-2591 #: Zhong-Tao Zhang and Feng Li contributed equally to the article : Co-corresponding author: Feng Li, Email: sxlifengwobuxin@sina.com, ORCID: 0000-0002-7322-422X
page: 10

INTRODUCTION

Over the last four decades, the world has experienced rapid demographic and epidemiological transitions. Rapid industrialization, urbanization, aging, and changes in lifestyle have led to a shift in the burden of the disease spectrum from infectious diseases to non‐communicable diseases. China has been an important contributor to the global cancer burden because of its large population. Among the cancer related deaths, Gastric cancer (GC) ranked fifth and was responsible for a significant mortality rates across the globe1. Particularly in China, the survivability of patients in after 5years is only 30 % after radical resection2, 3. Therefore, it is urgent to study the mechanism of GC occurrence and development4. MicroRNAs (miRNAs) are a family of small noncoding RNAs of 2022 nucleotides that regulate a wide array of biological processes including carcinogenesis. Under normal physiological conditions, miRNAs function in feedback mechanisms by safeguarding key biological processes including cell proliferation, differentiation and apoptosis5. However, in cancer cells, miRNAs have been found to be heavily dysregulated and are considered to play a pivotal role in the progression of a variety of tumors. It can reverse mediate about 30-40% of human genes by binding to the complementary 3 - non expression region (3 - UTR)6,7. Recent studies have shown that miR-147b is related to some cancers 8, which may be the tumor suppressor gene or oncogene. Over-expression of the miR-147b inhibitor or SOX15 can be seen through the Wnt/β-Catenin signal transduction pathway, delaying the growth of cancer cells in vivo. The role of miR-147b in GC is not clear; therefore, we have conducted the present study to elucidate its probable mechanism in GC.



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