MIR-147B REGULATED PROLIFERATION
AND APOPTOSIS OF GASTRIC CANCER CELLS
BY TARGETING CPEB2 VIA THE PTEN PATHWAY
Tao K.1,2, Dong J-H.2, Wang D.1, Li F.2†#, Zhang Z-T.#1*
*Corresponding Author: Zhong-Tao Zhang, MD, Email: sxzhangzhongtao@sina.com, ORCID ID: 0000-0002-1184-2591
#: Zhong-Tao Zhang and Feng Li contributed equally to the article
†: Co-corresponding author: Feng Li, Email: sxlifengwobuxin@sina.com, ORCID: 0000-0002-7322-422X
page: 10
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CONCLUSION
The above results suggest that the low expression
of CPEB2 in GC tissue is involved in the promoting the
proliferation, migration and invasion of GC cells. Finally,
PTEN controls a series of pathophysiological processes
related to cell proliferation, differentiation, DNA/chromosome
integrity, apoptosis, and invasiveness.
The deficiency of this study is that due to the impact
of the epidemic situation, no further animal carrier test
can be carried out.
At present, the detection of tumor derived miRNA
with abnormal expression in plasma can be used as an
important method for early detection of human cancer.
As a new non-invasive method, detecting the expression
of miRNA in peripheral blood may play a very important
role in early tumor detection, clear staging, judging curative
effect and evaluating prognosis. Whether miR-147b
can be used as a meaningful reference index is worthy of
further clinical exploration.
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