MIR-147B REGULATED PROLIFERATION AND APOPTOSIS OF GASTRIC CANCER CELLS BY TARGETING CPEB2 VIA THE PTEN PATHWAY
Tao K.1,2, Dong J-H.2, Wang D.1, Li F.2#, Zhang Z-T.#1*
*Corresponding Author: Zhong-Tao Zhang, MD, Email: sxzhangzhongtao@sina.com, ORCID ID: 0000-0002-1184-2591 #: Zhong-Tao Zhang and Feng Li contributed equally to the article : Co-corresponding author: Feng Li, Email: sxlifengwobuxin@sina.com, ORCID: 0000-0002-7322-422X
page: 10

CONCLUSION

The above results suggest that the low expression of CPEB2 in GC tissue is involved in the promoting the proliferation, migration and invasion of GC cells. Finally, PTEN controls a series of pathophysiological processes related to cell proliferation, differentiation, DNA/chromosome integrity, apoptosis, and invasiveness. The deficiency of this study is that due to the impact of the epidemic situation, no further animal carrier test can be carried out. At present, the detection of tumor derived miRNA with abnormal expression in plasma can be used as an important method for early detection of human cancer. As a new non-invasive method, detecting the expression of miRNA in peripheral blood may play a very important role in early tumor detection, clear staging, judging curative effect and evaluating prognosis. Whether miR-147b can be used as a meaningful reference index is worthy of further clinical exploration.



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