SINGLE NUCLEOTIDE POLYMORPHISMS IN IL-1A RS1800587, IL-1B RS1143634 AND VITAMIN D RECEPTOR RS731236 IN STAGE III GRADE B/C PERIODONTITIS
Özturk Özener H.1, Tacal Aslan B.2, Eken B.F.2, Agrali Ö.B.1, Yildrim H.S.1, Altunok E.Ç.3, Ulucan K.2, Kuru L.1
*Corresponding Author: Assist. Prof. Dr. Hafize Öztürk Özener, Address: Marmara University, Faculty of Dentistry, Department of Periodontology Basıbuyuk, Maltepe, Istanbul, Turkey. Fax number: +90 216 421 02 21; E-mail: hafize.ozturk@marmara.edu.tr
page: 10

CONCLUSION

In conclusion, CC genotype and C allele of TaqI polymorphism were associated with enhanced susceptibility to Stage III periodontitis in a Turkish study group. Furthermore, VDR TaqI polymorphism may be useful to discriminate between Grade B and Grade C in Stage III periodontitis. Identifying genetic risk factors according to the stage and grade of periodontitis will improve our knowledge about the pathophysiology and can potentially be used in defining individuals at risk of developing disease and predicting its progression rate. Funding: The present research was supported by Marmara University Scientific Research Project Commission, Istanbul, Turkey under grant agreement number: SAG-K-170118-0002. Declaration of Interest: The authors report no conflicts of interest. The authors alone are responsible for the content and writing of this article. Author Contributions: HOO: Methodology, Investigation, Data Curation, Writing - Original Draft, Project administration; BTA: Genetic analysis, Writing - review & editing; BFE: Genetic Analysis, Data Curation; ÖBA: Investigation, Writing - review & editing; HSY: Investigation, Data Curation, Writing - review & editing; EÇA: Data Curation, Statistical Data Analysis; KU: Methodology, Genetic Analysis, Writing - review & editing, LK: Methodology, Investigation, Writing - review & editing. All authors approved the final manuscript for publication.



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