SINGLE NUCLEOTIDE POLYMORPHISMS IN IL-1A RS1800587, IL-1B RS1143634 AND VITAMIN D RECEPTOR RS731236 IN STAGE III GRADE B/C PERIODONTITIS
Özturk Özener H.1, Tacal Aslan B.2, Eken B.F.2, Agrali Ö.B.1, Yildrim H.S.1, Altunok E.Ç.3, Ulucan K.2, Kuru L.1
*Corresponding Author: Assist. Prof. Dr. Hafize Öztürk Özener, Address: Marmara University, Faculty of Dentistry, Department of Periodontology Basıbuyuk, Maltepe, Istanbul, Turkey. Fax number: +90 216 421 02 21; E-mail: hafize.ozturk@marmara.edu.tr
page: 10

RESULTS

Table 1 demonstrates demographic data and clinical features of the periodontitis patients and the healthy subjects. All periodontal clinical parameters in the patients with periodontitis were significantly higher comparison to the healthy individuals, as expected (p<0.000). In Table 2, the distributions of polymorphisms in all study populations agreed to the Hardy–Weinberg equilibrium (p > 0.05), except IL-1B (rs1143634) in the healthy group (X2=7.75; p < 0.05). Comparisons of genotype frequencies between the periodontitis patients and healthy individuals are presented in Table 2. IL-1A (rs1800587) and IL-1B (rs1143634) polymorphisms did not show any association with periodontitis (OR=1.142, p=0.793, OR=1.726, p=0.371, respectively). Considering the VDR TaqI gene polymorphism, the frequencies of TT genotype in the periodontitis and healthy subjects were 36% and 49%, respectively, and CC genotype 19% and 10%, respectively. The results showed that the genotype CC was associated with a 2.586 times higher risk of periodontitis with a statistically significant risk coefficient (p=0.031). The allelic distributions of each gene polymorphisms are presented in Table 3. Allele frequency regarding IL-1A (rs1800587) demonstrated no significant differences between the healthy individuals and the periodontitis patients. The C allele in IL-1B (rs1143634) was detected more frequently in healthy individuals than patients (84.5% versus 76.5% OR=1.167, p=0.045). In VDR TaqI gene polymorphism, the C allele frequency in the periodontitis patients (83%) was higher than in the healthy subjects (61%). The C allele was statistically significant in the periodontitis patients with an OR of 1.61 (95% CI= 1.071–2.441, p=0.022). Model wise genotypic distributions regarding codominant, dominant, recessive and overdominant models are presented in Table 4. Model wise genotypic distribution of IL-1A (rs1800587) did not demonstrate any association with periodontitis (Table 4). Regarding the IL-1B (rs1143634) polymorphic region, the frequency of CC genotype was higher in healthy subjects and associated with a decreased risk of periodontitis under dominant model [OR (95% CI) =0.527 (0.289-0.960), p=0.035]. Likewise, VDR TaqI gene polymorphism showed alliance with periodontitis, on the other hand, the dominant, recessive and overdominant models did not demonstrate any relation with periodontitis (Table 4). Associations between different grades of periodontitis and gene polymorphisms in IL-1A (rs1800587), IL-1B (rs1143634) and VDR TaqI are demonstrated in Table 5. Both allele and genotype frequency of IL-1A (rs1800587) gene polymorphism did not show any association with any grade of periodontitis (p>0.05). The C and T alleles frequencies of IL-1B (rs1143634) polymorphism were 76 (74.5%) and 26 (25.5%) in the Grade B periodontitis, 77 (78.6%) and 21 (21.4%) in the Grade C periodontitis and 169 (84.5%) and 31 (15.5%) in the healthy subjects, respectively. The difference was found to be statistically significant only between the Grade B periodontitis and healthy subjects [OR=1.865; 95% CI (1.037-3.355), p=0.036]. A comparison of the VDR TaqI genotypes and alleles between the Grade B periodontitis and healthy subjects revealed that the TT genotype, and T allele were more frequently observed in the healthy subjects (TT vs. CC, TT vs. CT, T vs. C, p˂0.05). In the evaluation of TaqI polymorphism in Grade B and C periodontitis, individuals with the CT genotype have a 3.207 times higher risk of Grade B periodontitis than individuals with the TT genotype. [CT vs. TT, OR (95% CI) =3.207 (1.286-7.997), p=0.011].



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