SINGLE NUCLEOTIDE POLYMORPHISMS IN IL-1A
RS1800587, IL-1B RS1143634 AND VITAMIN D RECEPTOR
RS731236 IN STAGE III GRADE B/C PERIODONTITIS
Özturk Özener H.1, Tacal Aslan B.2, Eken B.F.2, Agrali Ö.B.1,
Yildrim H.S.1, Altunok E.Ç.3, Ulucan K.2, Kuru L.1
*Corresponding Author: Assist. Prof. Dr. Hafize Öztürk Özener, Address: Marmara University, Faculty
of Dentistry, Department of Periodontology Basıbuyuk, Maltepe, Istanbul, Turkey. Fax number: +90 216
421 02 21; E-mail: hafize.ozturk@marmara.edu.tr
page: 10
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Abstract
The purpose of the study is to determine the prevalence
of interleukin (IL)-1A (rs1800587), IL-1B (rs1143634) and
vitamin D receptor (VDR) (TaqI, rs731236) gene polymorphisms
in the Turkish population and their association
with Stage III Grade B/C periodontitis. Systemically and
periodontally healthy individuals (N = 100) and Stage III
Grade B/C periodontitis patients (N=100) based on clinical
and radiographic examination were included in this
research. Clinical attachment level, probing depth, bleeding
on probing, plaque and gingival indices of the subjects
were measured. Genotyping of IL-1A (rs1800587),
IL-1B (rs1143634) and VDR (rs731236) polymorphisms
was conducted by Real Time PCR. Allelic and genotypic
distributions of IL-1A (rs1800587) gene polymorphism
were not associated with periodontitis (p>0.05). In IL-1B
(rs1143634) gene polymorphism, the C allele was detected
more frequently in healthy individuals compared with
the periodontitis patients (p=0.045). CC genotype and C
allele in VDR (rs731236) gene polymorphism was higher
in periodontitis patients (p=0.031, p=0.034, respectively).
In comparison with Grade B periodontitis patients and
healthy subjects, CC genotype and C allele were observed
more frequently in the Grade B periodontitis in terms of
alleles (C/T) and genotypes for VDR (rs731236) polymorphism
(p=0.024, p=0.008, respectively). This study
presents that the VDR (rs731236) polymorphism are associated
with enhanced susceptibility to Stage III periodontitis
in the Turkish population. Furthermore, VDR
(rs731236) polymorphism may be used as an identification
criteria to discriminate Grade B and Grade C in Stage III
periodontitis.
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