SIMULTANEOUSLY BOTH EXPRESSION OF LMP-1 AND METHYLATION OF E-CADHERIN: MOLECULAR BIOMARKER IN STAGE IV OF NASOPHARYNGEAL CARCINOMA PATIENTS
Lao TD1, Truong PK1, Thieu HH1, Nguyen DH2, Nguyen MT3, Le TAH1,*
*Corresponding Author: Associate Professor Thuy A.H. Le, Department of Pharmaceutical and Medical Biotechnology, Ho Chi Minh City Open University, 35-37 Ho Hao Hon Street, Ho Chi Minh City, Vietnam. Tel.: +84-905-784-471. E-mail: thuy.lha@ou.edu.vn
page: 57

REFERENCES

1. Lao TD, Le TAH. MicroRNAs: Biogenesis, functions and potential biomarkers for early screening, prognosis and therapeutic molecular monitoring of nasopharyngeal carcinoma. Processes. 2020; 8(8): 966-1009. 2. Tabuchi K, Nakayama M, Nishimura B, Hayashi K, Hara A. Early detection of nasopharyngeal carcinoma. Int J Otolaryngol. 2011; 2011: 638058. 3. Li M, Wang C, Yu B, Zhang X, Shi F, Liu X. Diagnostic value of RASSF1A methylation for breast cancer: A meta-analysis. Biosci Rep. 2019; 39(6): BSR20190923. 4. Rowe M, Lear AL, Croom-Carter D, Davies AH, Rickinson AB. Three pathways of Epstein-Barr virus gene activation from EBNA1-positive latency in B lymphocytes. J Virol. 1992; 66(1): 122-131. 5. Vera-Sempere FJ, Burgos JS, Botella MS, Cordoba J, Gobernado M. Immunohistochemical expression of Epstein-Barr virus-encoded latent membrane protein (LMP-1) in paraffin sections of EBV-associated nasopharyngeal carcinoma in Spanish patients. Eur J Cancer B Oral Oncol. 1996; 32B(3): 163-168. 6. Young LS, Dawson CW, Eliopoulos AG. The expression and function of Epstein-Barr virus encoded latent genes. Mol Pathol. 2000; 53(5): 238-247. 7. Lao TD, Nguyen DH, Nguyen TM, Le TAH. Molecular screening for Epstein-Barr virus (EBV): Detection of genomic EBNA-1, EBNA-2, LMP-1, LMP-2 among Vietnamese patients with nasopharyngeal brush samples. Asian Pac J Cancer Prev. 2017; 18(6): 1675-1679. 8. Lao TD, Nguyen TAH, Ngo KD, Thieu HH, Nguyen MT, Nguyen DH, et al. Molecular screening of nasopharyngeal carcinoma: Detection of LMP-1, LMP-2 gene expression in Vietnamese nasopharyngeal swab samples. Asian Pac J Cancer Prev. 2019; 20(9): 2757- 2761. 9. Pathmanathan R, Prasad U, Sadler R, Flynn K, Raab- Traub N. Clonal proliferations of cells infected with Epstein-Barr virus in preinvasive lesions related to nasopharyngeal carcinoma. N Engl J Med. 1995; 333(11): 693-698. 10. Raab-Traub N. Epstein-Barr virus in the pathogenesis of NPC. Semin Cancer Biol. 2002; 12(6): 431-441. 11. Zhao Y, Wang Y, Zeng S, Hu X. LMP1 expression is positively associated with metastasis of nasopharyngeal carcinoma: evidence from a meta-analysis. J Clin Pathol. 2012; 65(1): 41-45. 12. Goodwin M, Yap AS. Classical cadherin adhesion molecules: Coordinating cell adhesion, signaling and the cytoskeleton. J Mol Histol. 2004; 35(9): 839-844. 13. Jeanes A, Gottardi CJ, Yap AS. Cadherins and cancer: How does cadherin dysfunction promote tumor progression? Oncogene. 2008; 27(55): 6920-6929. 14. Tsao SW, Liu Y, Wang XX, Yuen PW, Leung SY, Yuen ST, et al. The association of E-cadherin expression and the methylation status of the E-cadherin gene in nasopharyngeal carcinoma cells. Eur J Cancer. 2003; 39(4): 524-531. 15. Niemhom S, Kitazawa S, Kitazawa R, Maeda S, Leopairat J. Hypermethylation of epithelial-cadherin gene promoter is associated with Epstein-Barr virus in nasopharyngeal carcinoma. Cancer Detect Prev. 2008; 32(2): 127-134. 16. Ayadi W, Karray-Hakim H, Khabir A, Feki L, Charfi S, Boudawara T, et al. Aberrant methylation of p16, DLEC1, BLU and E-cadherin gene promoters in nasopharyngeal carcinoma biopsies from Tunisian patients. Anticancer Res. 2008; 28(4B): 2161-2167. 17. Ran Y, Wu S, You Y. Demethylation of E-cadherin gene in nasopharyngeal carcinoma could serve as a potential therapeutic strategy. J Biochem. 2011; 149(1): 49-54. 18. Ryan JL, Fan H, Glazer SL, Schichman SA, Raab- Traub N, Gulley ML. Epstein-Barr virus quantitation by real-time PCR targeting multiple gene segment: A novel approach to screen for the virus in paraffinembedded tissue and plasma. J Mol Diagn. 2004; 6(4): 378-385. 19. Al-Mozaini M, Bodelon G, Karsstegl CE, Jin B, Al- Ahdal M, Farrell PJ. Epstein-Barr virus BART gene expression. J Gen Virol. 2009; 90(Pt 2): 307-316. 20. Banko A, Lazarevic I, Cupic M, Stevanovic G, Boricic I, Jovanovic T. Carboxy-terminal sequence variation of LMP1 gene in Epstein-Barr-virus-associated mononucleosis and tumors from Serbian patients. J Med Virol. 2012; 84(4): 632-642. 21. Dawson CW, Port RJ, Young LS. The role of the EBVencoded latent membrane proteins LMP1 and LMP2 in the pathogenesis of nasopharyngeal carcinoma (NPC). Semin Cancer Biol. 2012; 22(2): 144-153. 22. Hao SP, Tsang NM, Chang KP, Ueng SH. Molecular diagnosis of nasopharyngeal carcinoma: Detecting LMP-1 and EBNA by nasopharyngeal swab. Otolaryngol Head Neck Surg. 2004; 131(5): 651-654. 23. See HS, Yap YY, Yip WK, Seow HF. Epstein-Barr virus latent membrane protein-1 (LMP-1) 30-bp deletion and Xho I-loss is associated with type III nasopharyngeal carcinoma in Malaysia. World J Surg Oncol. 2008; 6: 18-27. 24. Kang MS, Kieff E. Epstein-Barr virus latent genes. Exp Mol Med. 2015; 47(1): e131-e146. 25. Li Z, Lin SX, Liang YJ. Influence of E-cadherin promoter methylation and mutation of beta-catenin on invasion and metastasis of nasopharyngeal carcinoma cells. Zhonghua Zhong Liu Za Zhi. 2003; 25(3): 238-242. 26. Palmisano WA, Divine KK, Saccomanno G, Gilliland FD, Baylin SB, Herman JG, et al. Predicting lung cancer by detecting aberrant promoter methylation in sputum. Cancer Res. 2000; 60(21): 5954-5958. 27. Lin SX, Zong YS, Chu B, Zhong BL, Li Z, Liang YJ, et al. Relationship between the expressions of LMP-1 and e-cadherin/beta-catenin in nasopharyngeal carcinoma. Chin J Cancer Res. 2002; 14(3): 202-205. 28. Qiu X, Qiao F, Su X, Zhao Z, Fan H. Epigenetic activation of E-cadherin is a candidate therapeutic target in human hepatocellular carcinoma. Exp Ther Med. 2010; 1(3): 519-523. 29. Corso G, Bonanni B, Veronesi P. Tumor inactivation of E-cadherin: A new tool for breast cancer treatment? Ann Transl Med. 2018; 6(Suppl 1): S6. 30. Christman JK. 5-Azacytidine and 5-aza-2’-deoxycytidine as inhibitors of DNA methylation: Mechanistic studies and their implications for cancer therapy. Oncogene. 2002; 21(35): 5483-5495. 31. Nam JS, Ino Y, Kanai Y, Sakamoto M, Hirohashi S. 5-Aza-2’-deoxycytidine restores the E-cadherin system in E-cadherin-silenced cancer cells and reduces cancer metastasis. Clin Exp Metastasis. 2004; 21(1): 49-56. 32. Hannigan A, Wilson JB. Evaluation of LMP1 of Epstein-Barr virus as a therapeutic target by its inhibition. Mol Cancer. 2010; 9: 184.



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