SIMULTANEOUSLY BOTH EXPRESSION OF LMP-1 AND METHYLATION OF E-CADHERIN: MOLECULAR BIOMARKER IN STAGE IV OF NASOPHARYNGEAL CARCINOMA PATIENTS
Lao TD1, Truong PK1, Thieu HH1, Nguyen DH2, Nguyen MT3, Le TAH1,*
*Corresponding Author: Associate Professor Thuy A.H. Le, Department of Pharmaceutical and Medical Biotechnology, Ho Chi Minh City Open University, 35-37 Ho Hao Hon Street, Ho Chi Minh City, Vietnam. Tel.: +84-905-784-471. E-mail: thuy.lha@ou.edu.vn
page: 57

INTRODUCTION

A nasopharyngeal carcinoma (NPC) is a prevalent nasopharyngeal malignant tumor with remarkable differences in distribution that gravitates toward Southern Asia. Even though many improvements in NPC therapy have been achieved, the diagnosis at an advanced stage led to reducing the success rate of treatment as well as the survival of patients [1]. Thus, early screening and diagnosis represents beneficial opportunities to increase the survival of patients as well as the effects of nasopharyngeal cancer treatment. Because of the nonspecific symptoms related to the early stage of NPC as well as the deeply seated location of nasopharynx, it leads to major obstacles to early screening of NPC [2]. Therefore, effective biomarkers are truly needed [3]. According to the etiology of NPC, a strong association between the infection of Epstein-Barr virus (EBV), also known as human γ-herpesvirus 4 (HHV4), and NPC has been postulated [4-8]. In the stage of latency, the limited latent genes are expressed, have been reported to play the key role in nasopharyngeal tumorigenesis [9-11]. Among them, the latent membrane protein 1 (LMP-1) gene, its encoded protein, has profound effects on the proliferation as well as the metastasis of NPC cells, resulting in the highly invasive and malignant growth of nasopharyngeal tumors [10]. In addition to the expression of LMP-1, the establishment of an epigenetic change on the E-cadherin gene, located on chromosome 16q22.1, which is responsible for the main key mediator of cell-cell adhesion in epithelial tissue, by the forming of E-cadherin/catenin complex that is further linked to the actin cytoskeleton, is likely to be a major contributing factor to the development and metastasis of nasopharyngeal tumors [12,13]. Recent growing evidence indicated that the hypermethylation, a kind of epigenetic alteration of E-cadherin resulting in the silence of its function, has been reported to play a key role in NPC development and metastasis [14-17]. Are there any associations between the expression of LMP-1 and meth-ylation of E-cadherin in NPC tumorigenesis? And, emphatically, that is to determine whether a combination of LMP-1 expression and methylation of E-cadherin could be a significant molecular characteristic of nasopharyngeal carcinomas, as well as it could be the potential biomarker for NPC. To answer the issue mentioned above, the present case-control study was designed to explore the relationship in the expressions of LMP-1 and the hypermethylation of E-cadherin in NPC tumor and non cancerous specimens of Vietnamese population.



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