Balkan Journal of Medical Genetics

SIMULTANEOUSLY BOTH EXPRESSION OF LMP-1 AND METHYLATION OF E-CADHERIN: MOLECULAR BIOMARKER IN STAGE IV OF NASOPHARYNGEAL CARCINOMA PATIENTS
Lao TD1, Truong PK1, Thieu HH1, Nguyen DH2, Nguyen MT3, Le TAH1,*
*Corresponding Author: Associate Professor Thuy A.H. Le, Department of Pharmaceutical and Medical Biotechnology, Ho Chi Minh City Open University, 35-37 Ho Hao Hon Street, Ho Chi Minh City, Vietnam. Tel.: +84-905-784-471. E-mail: thuy.lha@ou.edu.vn
page: 57

INTRODUCTION

A nasopharyngeal carcinoma (NPC) is a prevalent nasopharyngeal malignant tumor with remarkable differences in distribution that gravitates toward Southern Asia. Even though many improvements in NPC therapy have been achieved, the diagnosis at an advanced stage led to reducing the success rate of treatment as well as the survival of patients [1]. Thus, early screening and diagnosis represents beneficial opportunities to increase the survival of patients as well as the effects of nasopharyngeal cancer treatment. Because of the nonspecific symptoms related to the early stage of NPC as well as the deeply seated location of nasopharynx, it leads to major obstacles to early screening of NPC [2]. Therefore, effective biomarkers are truly needed [3]. According to the etiology of NPC, a strong association between the infection of Epstein-Barr virus (EBV), also known as human γ-herpesvirus 4 (HHV4), and NPC has been postulated [4-8]. In the stage of latency, the limited latent genes are expressed, have been reported to play the key role in nasopharyngeal tumorigenesis [9-11]. Among them, the latent membrane protein 1 (LMP-1) gene, its encoded protein, has profound effects on the proliferation as well as the metastasis of NPC cells, resulting in the highly invasive and malignant growth of nasopharyngeal tumors [10]. In addition to the expression of LMP-1, the establishment of an epigenetic change on the E-cadherin gene, located on chromosome 16q22.1, which is responsible for the main key mediator of cell-cell adhesion in epithelial tissue, by the forming of E-cadherin/catenin complex that is further linked to the actin cytoskeleton, is likely to be a major contributing factor to the development and metastasis of nasopharyngeal tumors [12,13]. Recent growing evidence indicated that the hypermethylation, a kind of epigenetic alteration of E-cadherin resulting in the silence of its function, has been reported to play a key role in NPC development and metastasis [14-17]. Are there any associations between the expression of LMP-1 and meth-ylation of E-cadherin in NPC tumorigenesis? And, emphatically, that is to determine whether a combination of LMP-1 expression and methylation of E-cadherin could be a significant molecular characteristic of nasopharyngeal carcinomas, as well as it could be the potential biomarker for NPC. To answer the issue mentioned above, the present case-control study was designed to explore the relationship in the expressions of LMP-1 and the hypermethylation of E-cadherin in NPC tumor and non cancerous specimens of Vietnamese population.

Number 27 VOL. 27 (2), 2024	Number 27 VOL. 27 (1), 2024
Number 26 Number 26 VOL. 26(2), 2023 All in one	Number 26 VOL. 26(2), 2023
Number 26 VOL. 26, 2023 Supplement	Number 26 VOL. 26(1), 2023
Number 25 VOL. 25(2), 2022	Number 25 VOL. 25 (1), 2022
Number 24 VOL. 24(2), 2021	Number 24 VOL. 24(1), 2021
Number 23 VOL. 23(2), 2020	Number 22 VOL. 22(2), 2019
Number 22 VOL. 22(1), 2019	Number 22 VOL. 22, 2019 Supplement
Number 21 VOL. 21(2), 2018	Number 21 VOL. 21 (1), 2018
Number 21 VOL. 21, 2018 Supplement	Number 20 VOL. 20 (2), 2017
Number 20 VOL. 20 (1), 2017	Number 19 VOL. 19 (2), 2016
Number 19 VOL. 19 (1), 2016	Number 18 VOL. 18 (2), 2015
Number 18 VOL. 18 (1), 2015	Number 17 VOL. 17 (2), 2014
Number 17 VOL. 17 (1), 2014	Number 16 VOL. 16 (2), 2013
Number 16 VOL. 16 (1), 2013	Number 15 VOL. 15 (2), 2012
Number 15 VOL. 15, 2012 Supplement	Number 15 Vol. 15 (1), 2012
Number 14 14 - Vol. 14 (2), 2011	Number 14 The 9th Balkan Congress of Medical Genetics
Number 14 14 - Vol. 14 (1), 2011	Number 13 Vol. 13 (2), 2010
Number 13 Vol.13 (1), 2010	Number 12 Vol.12 (2), 2009
Number 12 Vol.12 (1), 2009	Number 11 Vol.11 (2),2008
Number 11 Vol.11 (1),2008	Number 10 Vol.10 (2), 2007
Number 10 10 (1),2007	Number 9 1&2, 2006
Number 9 3&4, 2006	Number 8 1&2, 2005
Number 8 3&4, 2004	Number 7 1&2, 2004
Number 6 3&4, 2003	Number 6 1&2, 2003
Number 5 3&4, 2002	Number 5 1&2, 2002
Number 4 Vol.3 (4), 2000	Number 4 Vol.2 (4), 1999
Number 4 Vol.1 (4), 1998	Number 4 3&4, 2001
Number 4 1&2, 2001	Number 3 Vol.3 (3), 2000
Number 3 Vol.2 (3), 1999	Number 3 Vol.1 (3), 1998
Number 2 Vol.3(2), 2000	Number 2 Vol.1 (2), 1998
Number 2 Vol.2 (2), 1999	Number 1 Vol.3 (1), 2000
Number 1 Vol.2 (1), 1999	Number 1 Vol.1 (1), 1998

About the journal ::: Editorial ::: Subscription ::: Information for authors ::: Contact