SIMULTANEOUSLY BOTH EXPRESSION OF LMP-1
AND METHYLATION OF E-CADHERIN:
MOLECULAR BIOMARKER IN STAGE IV OF
NASOPHARYNGEAL CARCINOMA PATIENTS
Lao TD1, Truong PK1, Thieu HH1, Nguyen DH2, Nguyen MT3, Le TAH1,*
*Corresponding Author: Associate Professor Thuy A.H. Le, Department of Pharmaceutical and Medical
Biotechnology, Ho Chi Minh City Open University, 35-37 Ho Hao Hon Street, Ho Chi Minh City,
Vietnam. Tel.: +84-905-784-471. E-mail: thuy.lha@ou.edu.vn
page: 57
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Abstract
The phenome of E-cadherin gene methylation and
the expression of latent membrane protein 1 (LMP-1) gene
are associated with nasopharyngeal carcinoma (NPC).
In order to determine whether cooperative LMP-1 expression
or methylation of E-cadherin could serve as the
potential molecule biomarker target for diagnosis and
therapy of NPC, a case-control study including 93 NPC
biopsy samples and 100 non cancerous nasopharyngeal
swab samples were examined, as well as the strength of
association among them by the quantitative polymerase
chain reaction (qPCR) and nested-methylation-specific
PCR methods. The significantly higher frequency of LMP-
1 expression and E-cadherin methylation in NPC biopsy
samples, accounting for 76.34 and 73.12%, respectively,
compared to non cancerous samples, accounting for 0.00
and 30.00%, respectively, were observed. The significant
correlation between the LMP-1 expression and E-cadherin
methylation in NPC samples was reported. In detail, in
the stage IV of NPC, in case of LMP-1-positive samples,
35 of 37 samples (accounting for 94.60%) were positive
for methylation of E-cadherin. It was demonstrated that
cooperative LMP-1 expression and E-cadherin gene methylation
could serve as a molecular biomarker in NPC.
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