PPARγ GENE AND ATHEROSCLEROSIS: GENETIC POLYMORPHISMS, EPIGENETICS AND THERAPEUTIC IMPLICATIONS
Grbić E, Peterlin A, Kunej T, Petrovič D
*Corresponding Author: Professor Daniel Petrovič, M.D., Ph.D., Institute of Histology and Embryology, Faculty of Medicine University Ljubljana, Vrazov trg 2, Ljubljana 1000, Slovenia. Tel: +386-1-5437-360. Fax: +386-1-5437-361. E-mail: Daniel.petrovic@mf.uni-lj.si
page: 39

CONCLUSIONS

There are conflicting views on the role of PPARG polymorphisms at the onset of atherosclerosis. The reason may be the different genetic background of the observed population. The current, meta-analyzes of the effects of PPAR polymorphism on the development of atherosclerosis are heterogeneous with an unclear conclusion. We believe it is important to perform meta-analysis only in Caucasian or Asian populations, due to the impact of different genetic or epigenetic factors, which would contribute to a better understanding of the impact of these factors on the onset and the development of atherosclerosis in different populations. Some studies were done on a small number of subjects, some had a low average life-span, therefore larger and prospective studies with homogeneous groups had to be carried out. It is also necessary to examine in more detail the effect of polymorphisms investigated at the onset of atherosclerosis and their role in T2DM patients. Many studies have shown a significant effect of epigenetic factors in the development and onset of atherosclerosis but also other CVDs. However, the mechanism of origin is not adequately described, which must be accurately determined. Namely, epigenetic studies of atherosclerosis can offer very good therapeutic solutions for CVDs and their prevention. Due to the contrary attitudes about the effect of TZDs therapy on the processes of atherosclerosis and the occurrence of adverse effects in T2DM patients with CVD, it is necessary to decisively investigate mechanisms of action of PPARγ agonists in order to prevent the onset and progression of atherosclerosis in T2DM patients. Declaration of Interest. The authors report no conflicts of interest. The authors alone are responsible for the content and writing of this article.



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