LACK OF ASSOCIATION BETWEEN VARIANTS WITHIN THE AHSG, HCRT AND NPY2R GENES AND ANTHROPOMETRICAL PARAMETERS IN CZECH POST-MONICA STUDY
Jurcikova L*, Adamkova V, Lanska V, Suchanek P, Hubacek JA
*Corresponding Author: Ing. Lucie Jurčíková, Institute for Clinical and Experimental Medicine, DEM, Videnska 1958/9, Prague 4, 14021, Czech Republic; Tel.: +420-261-362-229; Fax: +420-241-721-574; E-mail: jurl@ikem.cz
page: 63

DISCUSSION

The hypothesis of variants within the AHSG, NPY2R and HCRT genes being significant determinants of plasma lipids or obesity markers in the Czech population was not confirmed by this large population study. An association of AHSG concentration with triglyceride levels has been described [26], which is consistent with our results. In our large study, we also demonstrated a possible increase of total cholesterol in AHSG rs4917 T allele carriers. However, in our study, we did not confirm any other previous observations regarding its influence on low density lipo-proteins (LDL)-cholesterol, central obesity or blood glucose [27]. No significant impact of the rs4917 polymorphism on BMI, waist circumference or plasma levels of glucose was found, which supports the results of a previous study on Scandinavian women. In contrast to the Swedish study, where significant association between the rs4917 polymorphism and plasma cholesterol was found [3], in our study only triglycerides were significantly changed. No significant relationship between rs4917 AHSG variant and anthropometrical parameters or lipids was found in an interventional study of 105 unrelated overweight adult Czech females. However, CC homozygotes showed an increase of lean muscle mass, decrease of total body fat and increased basal metabolic rate per kg of body weight in contrast to T carriers [2]. Although no relationship between the NPY2R rs1047214 SNP was found in our study, some studies have described some effects. In Swedish men, the common T allele was associated with lower BMI [1]. In contrast, another study of selected UK adults connects the T allele with higher BMI. This could be explained by the inclusion of morbidly obese and, consequently, a higher BMI median than in the Swedish study [23]. This study also shows, apart from BMI, higher WHR in T allele carriers. Neither triglyceride nor glucose levels were influenced [1]. In the French study of NPY2R rs1047214, the T allele was associated with lower WHR, but not with BMI in boys and not with adults [21]. Minimum studies have focused on rs760282 HCRT variant. Similar to others [18], we did not find any association with obesity parameters. In conclusion, we are not able to confirm that polymorphisms within the AHSG, HCRT and NPY2R genes are major genetic determinants of BMI and plasma lipids in the Czech-Slavonic population.



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