LACK OF ASSOCIATION BETWEEN VARIANTS WITHIN THE AHSG, HCRT AND NPY2R GENES AND ANTHROPOMETRICAL PARAMETERS IN CZECH POST-MONICA STUDY
Jurcikova L*, Adamkova V, Lanska V, Suchanek P, Hubacek JA
*Corresponding Author: Ing. Lucie Jurčíková, Institute for Clinical and Experimental Medicine, DEM, Videnska 1958/9, Prague 4, 14021, Czech Republic; Tel.: +420-261-362-229; Fax: +420-241-721-574; E-mail: jurl@ikem.cz
page: 63
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Abstract

The aim of this study was to examine single nucleotide polymorphisms (SNPs) of candidate genes a2-Heremans-Schmid glycoprotein (AHSG, rs4917), Hypocretin (HCRT, rs760282) and Neuropetide Y2 receptor (NPY2R, rs 1047214), which are known to have a potential effect on body mass index (BMI) and other indicators of obesity. A population study was performed in 2007/2008 on 2559 adults (1191 males and 1368 females) from the Czech post-MONICA project. The SNPs were examined using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. We did not find any significant association between the examined SNPs and BMI across the whole population. A significantly lower triglyceride level was found in the AHSG gene CC homozygotes compared to T allele carriers in the entire population (p = 0.009). In conclusion, we are not able to confirm the hypothesis that polymorphisms within the AHSG, HCRT and NPY2R genes are major genetic determinants of BMI and plasma lipids in the Czech-Slavonic population.



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