LACK OF ASSOCIATION BETWEEN VARIANTS WITHIN THE
AHSG, HCRT AND NPY2R GENES AND ANTHROPOMETRICAL
PARAMETERS IN CZECH POST-MONICA STUDY
Jurcikova L*, Adamkova V, Lanska V, Suchanek P, Hubacek JA
*Corresponding Author: Ing. Lucie Jurčíková, Institute for Clinical and Experimental Medicine, DEM, Videnska
1958/9, Prague 4, 14021, Czech Republic; Tel.: +420-261-362-229; Fax: +420-241-721-574; E-mail: jurl@ikem.cz
page: 63
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Abstract
The aim of this study was to examine single nucleotide
polymorphisms (SNPs) of candidate genes
a2-Heremans-Schmid glycoprotein (AHSG, rs4917),
Hypocretin (HCRT, rs760282) and Neuropetide Y2 receptor
(NPY2R, rs 1047214), which are known to have
a potential effect on body mass index (BMI) and other
indicators of obesity. A population study was performed
in 2007/2008 on 2559 adults (1191 males and
1368 females) from the Czech post-MONICA project.
The SNPs were examined using the polymerase chain
reaction-restriction fragment length polymorphism
(PCR-RFLP) method. We did not find any significant
association between the examined SNPs and BMI
across the whole population. A significantly lower
triglyceride level was found in the AHSG gene CC
homozygotes compared to T allele carriers in the entire
population (p = 0.009). In conclusion, we are not
able to confirm the hypothesis that polymorphisms
within the AHSG, HCRT and NPY2R genes are major
genetic determinants of BMI and plasma lipids in the
Czech-Slavonic population.
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