LACK OF ASSOCIATION BETWEEN VARIANTS WITHIN THE
AHSG, HCRT AND NPY2R GENES AND ANTHROPOMETRICAL
PARAMETERS IN CZECH POST-MONICA STUDY
Jurcikova L*, Adamkova V, Lanska V, Suchanek P, Hubacek JA
*Corresponding Author: Ing. Lucie Jurčíková, Institute for Clinical and Experimental Medicine, DEM, Videnska
1958/9, Prague 4, 14021, Czech Republic; Tel.: +420-261-362-229; Fax: +420-241-721-574; E-mail: jurl@ikem.cz
page: 63
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RESULTS
The frequencies of the examined genotypes
were similar to the previously analyzed populations
in AHSG [4,7,8], HCRT [18] and NPY2R [1,21,23].
The number and percentage of individual genotypes
and call rates are summarized in Table 3. No association
between polymorphisms and BMI or waist-hip
ratio (WHR) was found. No interaction between gene
and gender was found.
The relationship between genotype and phenotype
was observed for the AHSG gene. A significantly
lower triglyceride level was found in the CC genotype
(p = 0.0302) compared with CT and TT genotypes in
the group involving both genders. After using the CC
vs. T carriers model, the p value decreased to 0.0088. The same SNP showed a slight trend in influencing the
total cholesterol level (p = 0.06) in codominant model
and p = 0.057 in model C vs. TT carriers.
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