COMPARATIVE ANALYSIS OF GENES
ASSOCIATED WITH OBESITY IN HUMANS
USING BIOINFORMATIC DATA AND TOOLS
Musliji ZS1, Pollozhani AK1, Lisichkov K2, Deligios M3, Popovski ZT2,4,*
*Corresponding Author: Professor Zoran T. Popovski, Ph.D., Department of Biochemistry and
Genetic Engineering, Faculty of Agriculture and Food Sciences, Bld “Aleksandar Makedonski,” bb
PB 297, 1000 Skopje, Republic of North Macedonia. Tel: +389-70-252-731. Fax: +389-2-3134-310.
E-mail: zoran_ popovski@yahoo.com
page: 35
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Abstract
Obesity has become a serious global problem that still
needs a solution. One of the factors that leads to obesity is
genetic predisposition. The identity and characteristics of the
genes involved have not yet been fully confirmed. Analyzing
the genetic contribution to obesity is a major step towards the
solution. In this in silico study, using online bioinformatics
tools, we evaluate the role of four genes that are believed to
contribute to obesity. Data were collected and analyzed for
the sequences of four so-called obesity genes: FTO (fat mass
and obesity-associated protein), PPARG (peroxisome proliferator
activated receptor γ), ADRB3 (adrenergic receptor β
3) and FABP2 (fatty acid binding protein 2). In the first part
of the research, information about the genes was collected
and organized and data in FASTA, format are extracted from
the National Center for Biotechnology Information (NCBI).
In the second part, all genes were analyzed by comparing
three species of organisms, Homo sapiens (human), Mus
musculus (mouse) and Gallus (chicken). In the third part of
this study, phylogenetic trees were constructed for each of the
four genes, using blast local alignment search tool (BLAST)
and molecular evolutionary genetics analysis (MEGA X)
software. Our analysis reveals that the functions of all these
genes are associated with overweight and obesity.
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