ASSOCIATIONS OF BIOCHEMICAL CHANGES AND
MATERNAL TRAITS WITH MUTATION 1843 (C>T)
IN THE RYR1 GENE AS A COMMON CAUSE
FOR PORCINE STRESS SYNDROME
Popovski ZT, Tanaskovska B, Miskoska-Milevska E, Andonov S, Domazetovska S
*Corresponding Author: Professor Zoran T. Popovski, Ph.D., Faculty of Agriculture and Food Sciences, Bld “Aleksandar
Makedonski,” bb PB 297, 1000 Skopje, Republic of Macedonia. Tel: +389-70-252-731. Fax: +389-2-3134-310. E-mail:
zoran_popovski@yahoo.com
page: 75
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Abstract
Stress syndrome is usually caused by a mutation in
the ryanodine receptor gene (ryr1) and it is widely studied
in humans and swine populations. The protein product of
this gene plays a crucial role in the regulation of calcium
transport in muscle cells. A G>T mutation in the human
ryr1 gene, which results in the replacement of a conserved
arginine at position 614 where a leucine occurs at the same
position as the previously identified Arg→Cys mutation
reported in all cases of porcine stress syndrome (PSS).
Porcine stress syndrome affects biochemical pathways in
stress-susceptible individuals during a stress episode and
some biochemical parameters that were used as markers
for diagnostic purposes. Also, PSS has remarkable influence
on the maternal characteristics of sows. This study
dealt with different genotypes for PSS and its association
with possible biochemical changes and maternal traits of
sows. Seventy-three reproductive sows genotyped for PSS
by polymerase chain reaction-restriction fragment length
polymorphism (PCR-RFLP) were included in this survey.
Sixty of them were stress-free (NN), 11 were heterozygous
carriers (Nn) and two animals were homozygous (nn) for
the 1843 (C>T) mutation. Significant differences in non
stress induced animals with different PSS genotypes were
found in the values of creatine phoshokinase (CPK), lactate
dehydrogenase (LDH), alkaline phosphatase (AP) and
aspartate aminotransferase (AST). Regarding the maternal
traits, our study showed that stress susceptible animals (nn)
have an increased number of stillborn piglets and a reduced
number of newborn piglets compared with heterozygous
and normal animals.
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