THE COMT GENE: ASSOCIATION WITH SCHIZOPHRENIA AND AGGRESSIVE BEHAVIOR
Zainullina A. 1, Gaysina D. 1, Jurjev E. 1, Ghabdulhatov R. 2, Gumerova R.3, Khusnutdinova E.1
*Corresponding Author: Mrs. Aigul Zainullina, Department of Human Genomic, Institute of Biochemistry and Genetics, Ufa Scientific Center of Russian Academy of Sciences; 69 Octyabrya Avenue, Ufa, 450054, Russia. Telephone number: +7 3472 356088. Fax number: +7 3472 356100. E-mail: aigul_zainullina@mail.ru, dgaisina@mail.ru
page: 51

DISCUSSION

Our data of COMT genotype and allele frequency in our control group is in agreement with the data of Parliament [5] for Russian population (49% - COMT*H, 51% - COMT*L) and for some other European populations (Finns, Irish).

Literature data of the COMT gene investigations in schizophrenia and behavioral disorders are controversial. R.D. Strous et al. [12] reported that schizophrenic patients (N=37) who were homozygous for the low activity allele (COMT*L) were judged to be at higher risk for aggressive and dangerous behavior that those who were homozygous for the high activity allele (COMT*H).

H.H. Lachman et al. [3] reported association between the COMT*L/*L genotype and aggressive behavior in schizophrenic and schizoaffective patients (N=55). Control group consisted of patients without aggressive behavior.

M. Kotler et al. [14] investigated the character of COMT genotype distribution in 3 groups: homicidal schizophrenic patents (N=30), nonviolent schizophrenic patients (N=62) and control subjects (N=415). Significant excess homozygosity of COMT*L/*L was observed only in homicidal schizophrenic group compared with healthy control group. K.A. Nolan et al. [15] revealed that the COMT*L allele was more frequent in males with schizophrenia who had attempted suicide by violent means.

These findings support a hypothesis of common neurobiological substrate for self- and out-directed aggression. In the present study we found the Val158/108Met polymorphism of the COMT gene was associated with both self - and out - directed aggressive behavior in subjects without diagnosis of schizophrenia. According to family, twin and adoption studies patients with schizophrenia tend to have an increased risk of aggressive behavior [18]. We suggest that catecholaminergic alterations may contribute to these behaviors independently from such psychiatric disorder as schizophrenia.

All above-mentioned studies have reported a significant association between the COMT low activity genotype and allele and aggressive behavior in schizophrenic patients. However, G. Jones et al. [19] found association between the COMT*H/*H genotype and higher level of aggression in schizophrenic patients (N=180). So, our data is in agreement with this study. We suggest that the COMT*H/*H genotype is a marker of increased risk for schizophrenia (OR=2.56, 95%CI 1.60-4.12), both out-directed (OR=1.84, 95%CI 1.08-3.16) and in-directed aggressive behavior (OR=2.28, 95%CI 1.39-3.77).

But in some studies association between the COMT genotypes and schizophrenia were not seen [20, 21]. Some reasons for controversial results can be possible. Mental diseases this combination of various symptoms, which, unfortunately, not always allow dividing the patients precisely using certain phenotype criteria. Problem of exact and authentic diagnostics of mental distresses seems to be especially important. Differential diagnostics in psychiatry is based on careful analysis of all symptoms and traits of disease, complaints of the patient, of behavior features, etc. Also the structured questionnaires and quantitative diagnostic criteria are used frequently in psychiatric practice. Some diagnostic systems are too circumscribed and specialized; on the contrary, others include superfluous quantity of assessments. Therefore validity of any diagnosis remains the main problem in psychiatry.

Secondly, the different explorers dealt with groups of the patients with a various degree of aggressive behavior and probably with other forms of schizophrenia. In the present study persons with extremely high level of aggression (murder, numerous physical offences, attempt of suicide by violent means) and patients with paranoid schizophrenia were included.

Thirdly, in comparison with samples of the patients in the previous researches of mental distresses, the sample of the persons in our work was much more: 236 patients with paranoid schizophrenia, 182 suicide attempters, 182 violent offenders and 203 healthy subjects.

At last, the controversial results can be explained by features of genetical structure of populations, which the samples of the surveyed persons were enrolled from.

 




Number 26
VOL. 26(1), 2023
Number 25
VOL. 25(2), 2022
Number 25
VOL. 25 (1), 2022
Number 24
VOL. 24(2), 2021
Number 24
VOL. 24(1), 2021
Number 23
VOL. 23(2), 2020
Number 22
VOL. 22(2), 2019
Number 22
VOL. 22(1), 2019
Number 22
VOL. 22, 2019 Supplement
Number 21
VOL. 21(2), 2018
Number 21
VOL. 21 (1), 2018
Number 21
VOL. 21, 2018 Supplement
Number 20
VOL. 20 (2), 2017
Number 20
VOL. 20 (1), 2017
Number 19
VOL. 19 (2), 2016
Number 19
VOL. 19 (1), 2016
Number 18
VOL. 18 (2), 2015
Number 18
VOL. 18 (1), 2015
Number 17
VOL. 17 (2), 2014
Number 17
VOL. 17 (1), 2014
Number 16
VOL. 16 (2), 2013
Number 16
VOL. 16 (1), 2013
Number 15
VOL. 15 (2), 2012
Number 15
VOL. 15, 2012 Supplement
Number 15
Vol. 15 (1), 2012
Number 14
14 - Vol. 14 (2), 2011
Number 14
The 9th Balkan Congress of Medical Genetics
Number 14
14 - Vol. 14 (1), 2011
Number 13
Vol. 13 (2), 2010
Number 13
Vol.13 (1), 2010
Number 12
Vol.12 (2), 2009
Number 12
Vol.12 (1), 2009
Number 11
Vol.11 (2),2008
Number 11
Vol.11 (1),2008
Number 10
Vol.10 (2), 2007
Number 10
10 (1),2007
Number 9
1&2, 2006
Number 9
3&4, 2006
Number 8
1&2, 2005
Number 8
3&4, 2004
Number 7
1&2, 2004
Number 6
3&4, 2003
Number 6
1&2, 2003
Number 5
3&4, 2002
Number 5
1&2, 2002
Number 4
Vol.3 (4), 2000
Number 4
Vol.2 (4), 1999
Number 4
Vol.1 (4), 1998
Number 4
3&4, 2001
Number 4
1&2, 2001
Number 3
Vol.3 (3), 2000
Number 3
Vol.2 (3), 1999
Number 3
Vol.1 (3), 1998
Number 2
Vol.3(2), 2000
Number 2
Vol.1 (2), 1998
Number 2
Vol.2 (2), 1999
Number 1
Vol.3 (1), 2000
Number 1
Vol.2 (1), 1999
Number 1
Vol.1 (1), 1998

 

 


 About the journal ::: Editorial ::: Subscription ::: Information for authors ::: Contact
 Copyright © Balkan Journal of Medical Genetics 2006