THE COMT GENE: ASSOCIATION WITH SCHIZOPHRENIA AND AGGRESSIVE BEHAVIOR
Zainullina A. 1, Gaysina D. 1, Jurjev E. 1, Ghabdulhatov R. 2, Gumerova R.3, Khusnutdinova E.1
*Corresponding Author: Mrs. Aigul Zainullina, Department of Human Genomic, Institute of Biochemistry and Genetics, Ufa Scientific Center of Russian Academy of Sciences; 69 Octyabrya Avenue, Ufa, 450054, Russia. Telephone number: +7 3472 356088. Fax number: +7 3472 356100. E-mail: aigul_zainullina@mail.ru, dgaisina@mail.ru
page: 51

RESULTS

The data of COMT genotype and allele frequencies in study groups is presented in Table 1. The frequency of the COMT*L/*L genotype in controls (22%) was similar to that previously reported in European populations [5].The frequencies of alleles were nearly equal in the control group: 48% (COMT*H) and 52% (COMT*L).

Significant differences were found in the genotype frequencies between controls and subjects with schizophrenia (χ2=17.06, P=0.001, df=2), out-directed aggressive behavior (χ2=8.27, P=0.02, df=2), and self-directed aggressive behavior (χ2=12.12, P=0.004, df=2).

The significant increase of the COMT*H/*H genotype frequency was observed in the group of schizophrenic patients (χ2=17.06, P=0.0005, df=1, OR=2.56, 95%CI 1.60-4.12), both the group of subjects with out-directed aggressiveness (χ2=5.05, P=0.025, df=1, OR=1.84, 95%CI 1.08-3.16) and the group of subjects with suicidal behavior (χ2=11.19, P=0.0016, df=1, OR=2.28, 95%CI 1.39-3.77).

The frequency of the COMT*H/*L genotype seemed to be lower in schizophrenic group (χ2=7.24, P=0.009, df=1, OR=0.57, 95%CI 0.38-0.85), while the COMT*L/*L genotype had lower frequency in the group with out-directed aggressive behavior (χ2=4.29, P=0.038, df=1, OR=0.54, 95%CI 0.30-0.97).

In all investigated groups the frequency of the COMT*H allele was higher than the COMT*L allele. Significant differences were found in allele frequencies between controls and schizophrenic group (χ2=14.37, P=0.003, df=1), out-aggressive behavior group (χ2=6.70, P=0.01, df=1) and suicidal group (χ2=7.87, P=0.006, df=1).

So, according to our data the Val158/108Met polymorphism of the COMT gene is associated with schizophrenia and different forms of aggressive behavior.

 

Table 1. Genotype and allele frequencies of the COMT gene Val158/108Met polymorphism in investigated groups

 

Groups

N

p sp (95%CI)

genotypes

alleles

*H/*H

*H/*L

*L/*L

*H

*L

Control

203

0.18 0.03

(0.13-0.24)

0.60 0.03

(0.53-0.67)

0.22 0.03

(0.17-0.29)

0.48 0.02

(0.43-0.53)

0.52 0.02

(0.44-0.57)

Schizophrenia

236

0.36 0.03

(0.29-0.42)

0.46 0.03

(0.40-0.53)

0.18 0.03

(0.14-0.24)

0.59 0.02

(0.54-0.63)

0.41 0.02

(0.37-0.46)

Aggressive behavior

   out-directed

 

 

182

 

 

 

0.30 0.03

(0.23-0.37)

 

 

 

0.56 0.04

(0.49-0.63)

 

 

 

0.14 0.03

(0.10-0.20)

 

 

 

0.58 0.03

(0.52-0.63)

 

 

 

0.42 0.03

(0.37-0.48)

   in-directed

182

 

0.33 0.03

(0.26-0.40)

 

0.50 0.04

(0.43-0.58)

 

0.17 0.03

(0.12-0.23)

 

0.58 0.03

(0.53-0.63)

 

0.42 0.03

(0.37-0.47)

 

N value, sp frequency mistake, 95%CI confidential interval,

 




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