ASSOCIATIONS BETWEEN VASPIN RS2236242 GENE
POLYMORPHISM, WALKING TIME AND THE RISK
OF METABOLIC SYNDROME
Suliga E1, Kozieł D2, Cieśla E3, Rębak D2, Wawszczak M2,*,
Adamus-Białek W2, Naszydłowska E4, Piechowska A2, Głuszek S2
*Corresponding Author: Monika Wawszczak, MSc, Department of Surgery and Surgical Nursery with Genetics
and Research Laboratory, Institute of Medical Sciences, Jan Kochanowski University, al. IX Wieków
Kielc 19a, 25-516, Kielce, Poland. Tel: +48-413696978. E-mail: mwawszczak@ujk.edu.pl
page: 41
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INTRODUCTION
Vaspin (visceral adipose tissue-derived serine protease
inhibitor) was isolated for the first time from visceral
adipose tissue in Otsuka Long-Evans Tokushima Fatty rats,
which comprises an animal model of abdominal obesity,
accompanied by type 2 diabetes mellitus (T2DM) [1].
Human vaspin mRNA has been found both in the visceral
and in subcutaneous adipose tissue. It is coded by the gene
SERPNA12 located on the long arm of chromosome 14
(14q32.13) and consists of five introns and six exons. According
to the literature review, there is a positive association
between the vaspin concentration in the blood serum
and the indicators of obesity, T2DM, polycystic ovary
syndrome (PCOS) and coronary artery disease (CAD)
[1,2]. Feng et al. [2] after the meta-analysis of the scores
of six studies involving 1826 participants, revealed that
the vaspin levels were aproximately 0.52 ng/mL higher
in obese patients than in controls. However, some studies
showed a lack of associations between the level of
vaspin and obesity [3,4]. Several researchers suggest that
this adipokin increases the insulin sensitivity of adipose
tissue in the condition of obesity. The increase of vaspin
expression acts like a compensatory mechanism and being
a reaction to growing obesity and insulin resistance.
Several studies have revealed that vaspin concentration is related to a better metabolic profile and that its levels
in the blood serum are significantly higher in individuals
with metabolic syndrome (MetS) than in control [5,6].
So far, only a few studies devoted to the analysis of the
relationships between vaspin gene polymorphism and the
risk of MetS have been published [6-8]. Studies conducted
by Hashemi et al. [7] and Mehanna et al. [8] confirmed
that the risk of MetS was significantly lower in allele A
rs2236242 carriers. On the other hand, Alnory et al. [6] in
the studies involving the Egyptian population, did not find
any differences between the frequency of vaspin rs2236242
genotypes and the risk of MetS. Therefore, it was stated
that there are only a few studies concerning association
between vaspin gene polymorphism and MetS, and their
results are ambiguous. No such study has been conducted
in the Polish population. According to our current knowledge,
none of the previously published studies considered
relationship between vaspin rs2236242 polymorphism and
the risk of MetS including physical activity or walking.
Therefore, the aim of the study was the analysis of the associations
between vaspin rs2236242 polymorphism and
physical activity in relation to MetS and its components.
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