ASSOCIATIONS BETWEEN VASPIN RS2236242 GENE
POLYMORPHISM, WALKING TIME AND THE RISK
OF METABOLIC SYNDROME
Suliga E1, Kozieł D2, Cieśla E3, Rębak D2, Wawszczak M2,*,
Adamus-Białek W2, Naszydłowska E4, Piechowska A2, Głuszek S2
*Corresponding Author: Monika Wawszczak, MSc, Department of Surgery and Surgical Nursery with Genetics
and Research Laboratory, Institute of Medical Sciences, Jan Kochanowski University, al. IX Wieków
Kielc 19a, 25-516, Kielce, Poland. Tel: +48-413696978. E-mail: mwawszczak@ujk.edu.pl
page: 41
download article in pdf format
|
|
Abstract
The associations between serum vaspin levels and
metabolic or coronary artery disease (CAD) and polycystic
ovary syndrome (PCOS) is under the scope of current researchers.
Therefore, this adipokine can be considered as a
biomarker of metabolic syndrome (MetS). The aim of the
study was to analyze the associations between the vaspin
rs2236242 polymorphism and physical activity in relation
to MetS and its components. The analysis involved the
genetic material and clinical data of 108 individuals with
MetS and 110 controls. Vaspin rs2236242 polymorphism
was detected using the tetra-primer amplification-refractory
mutation system polymerase chain reaction (T-ARMS
PCR) method. The TA genotype of vaspin rs2236242 was
associated with a greater risk of MetS and its components
compared with the TT genotype. The analysis of interactions
between genotype and walking time revealed that
a walking time longer than 60 min./day significantly decreased
the risk of MetS in the TA carriers (p = 0.007). The
obtained results suggest that any unfavorable effect of the
TA genotype of the vaspin rs2236242 polymorphism can
be essentially reduced, or even reversed, in a case of individuals
walking longer than 60 min. a day. The analysis of
the interaction between vaspin rs2236242 polymorphism
and walking showed that a walking time of longer than 1
hour a day significantly reduced the risk of MetS, elevated
blood pressure and triglycerides concentration.
|
|
|
|
 |
Number 27
VOL. 27 (1), 2024 |
Number 26
Number 26 VOL. 26(2), 2023 All in one |
Number 26
VOL. 26(2), 2023 |
Number 26
VOL. 26, 2023 Supplement |
Number 26
VOL. 26(1), 2023 |
Number 25
VOL. 25(2), 2022 |
Number 25
VOL. 25 (1), 2022 |
Number 24
VOL. 24(2), 2021 |
Number 24
VOL. 24(1), 2021 |
Number 23
VOL. 23(2), 2020 |
Number 22
VOL. 22(2), 2019 |
Number 22
VOL. 22(1), 2019 |
Number 22
VOL. 22, 2019 Supplement |
Number 21
VOL. 21(2), 2018 |
Number 21
VOL. 21 (1), 2018 |
Number 21
VOL. 21, 2018 Supplement |
Number 20
VOL. 20 (2), 2017 |
Number 20
VOL. 20 (1), 2017 |
Number 19
VOL. 19 (2), 2016 |
Number 19
VOL. 19 (1), 2016 |
Number 18
VOL. 18 (2), 2015 |
Number 18
VOL. 18 (1), 2015 |
Number 17
VOL. 17 (2), 2014 |
Number 17
VOL. 17 (1), 2014 |
Number 16
VOL. 16 (2), 2013 |
Number 16
VOL. 16 (1), 2013 |
Number 15
VOL. 15 (2), 2012 |
Number 15
VOL. 15, 2012 Supplement |
Number 15
Vol. 15 (1), 2012 |
Number 14
14 - Vol. 14 (2), 2011 |
Number 14
The 9th Balkan Congress of Medical Genetics |
Number 14
14 - Vol. 14 (1), 2011 |
Number 13
Vol. 13 (2), 2010 |
Number 13
Vol.13 (1), 2010 |
Number 12
Vol.12 (2), 2009 |
Number 12
Vol.12 (1), 2009 |
Number 11
Vol.11 (2),2008 |
Number 11
Vol.11 (1),2008 |
Number 10
Vol.10 (2), 2007 |
Number 10
10 (1),2007 |
Number 9
1&2, 2006 |
Number 9
3&4, 2006 |
Number 8
1&2, 2005 |
Number 8
3&4, 2004 |
Number 7
1&2, 2004 |
Number 6
3&4, 2003 |
Number 6
1&2, 2003 |
Number 5
3&4, 2002 |
Number 5
1&2, 2002 |
Number 4
Vol.3 (4), 2000 |
Number 4
Vol.2 (4), 1999 |
Number 4
Vol.1 (4), 1998 |
Number 4
3&4, 2001 |
Number 4
1&2, 2001 |
Number 3
Vol.3 (3), 2000 |
Number 3
Vol.2 (3), 1999 |
Number 3
Vol.1 (3), 1998 |
Number 2
Vol.3(2), 2000 |
Number 2
Vol.1 (2), 1998 |
Number 2
Vol.2 (2), 1999 |
Number 1
Vol.3 (1), 2000 |
Number 1
Vol.2 (1), 1999 |
Number 1
Vol.1 (1), 1998 |
|
|
|
