DETECTING EGFR MUTATIONS IN PATIENTS WITH NON-SMALL CELL LUNG CANCER
Hammoudeh ZA, Antonova O, Staneva R, Nikolova D, Kyuchukov Y, Penev A, Mintchev T, Koleva V, Hadjidekova S, Toncheva D
*Corresponding Author: Zora A. Hammoudeh, Molecular Biologist, Department of Medical Genetics, Medical University Sofia, 2 Zdrave Str., 1431 Sofia, Bulgaria. Tel: +359-2-917-2735. Mobile: +359-88-943-0505. E-mail: zorahammoudeh@yahoo.com
page: 13

CONCLUSIONS

Our results show that in the Bulgarian NSCLC population the frequency of EGFR gene mutations is in the lower range of the one reported in other European populations. The EGFR gene mutation status can be accurately and quickly determined by the commercially available RTPCR assays. Our results showed that activating EGFR gene mutations are statistically more prevalent in women vs. men, in adenocarcinomas vs. other histological types and in non smokers vs. smokers. The commercially available RT-PCR assays efficiently detect the clinically significant EGFR gene mutations and are a first-tier test to determine EGFR status in a routine diagnostic setting. Declaration of Interest. The authors report no conflicts of interest. The authors alone are responsible for the content and writing of this article.



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