Balkan Journal of Medical Genetics

INDIVIDUAL PHENOTYPE TRAIT VARIABILITY AS GENETIC MARKERS OF GENDER SUSCEPTIBILITY TO SPINA BIFIDA
Nikolic DP1,*, Cvjeticanin S2,3, Petronic I1,2, Brdar R2,4, Cirovic D1,2, Bizic M4, Milincic Z1,2, Karan R5
*Corresponding Author: Dejan P. Nikolic, Physical Medicine and Rehabilitation, University Children’s Hospital, Nikole Stefanovica 3, 11000 Belgrade, Serbia; Tel.: +38-1-638-133-345; Email: denikol27@yahoo.com
page: 11

DISCUSSION

Our findings indicate a difference in individual trait variability between males and females for the predisposition to SB and to the expression of SB (SBO or SBA). A difference in genetic variability between healthy individuals and those with a diagnosed SB was reported by Nikolic et al. [19], but the possible role of gender for the SB individuals has not yet been observed regarding the individual traits variability. The present variability in the proportion of certain observed traits between genders in the control groups have been noticed in previous studies as well. For example, in the study of Ziering and Krenitzky [20], frequent opposite hair whorl orientation was observed in the male population. Reiss and Reiss [21] have presented that left-handedness was more frequent in males, while in the study of Gillam et al. [22], a longer index finger than the ring finger was frequently recorded in the female population. Our findings clearly show that there are differences in the distribution of certain phenotype traits between genders in control groups and in SBO and SBA patients, giving us the assumption of different predisposition to SBO and SBA between genders and the possibility of a correlation with different combinations of polygenes in these subjects. Such differences, stress the possibility of different, more specific phenotype existence for SBO or SBA regarding gender. From this point of view, it could be assumed that certain genes determining observed phenotypes that differ remarkably between genders in these subjects could have influence, to a certain degree, on the adaptability potential of the organism with the present SBO or SBA, to the specific environmental factors that could interfere during embryo genesis processes [14]. Since the genes for evaluated HRT are located on different chromosomes, they are considered not just the markers of such chromosomes, but the markers of the groups of surrounding polygenes that may have influence to a different degree on the development of SB and expression of SBO or SBA.

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