INDIVIDUAL PHENOTYPE TRAIT VARIABILITY
AS GENETIC MARKERS OF GENDER SUSCEPTIBILITY
TO SPINA BIFIDA
Nikolic DP1,*, Cvjeticanin S2,3, Petronic I1,2, Brdar R2,4,
Cirovic D1,2, Bizic M4, Milincic Z1,2, Karan R5
*Corresponding Author: Dejan P. Nikolic, Physical Medicine and Rehabilitation, University Children’s Hospital,
Nikole Stefanovica 3, 11000 Belgrade, Serbia; Tel.: +38-1-638-133-345; Email: denikol27@yahoo.com
page: 11
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Abstract
We compared individual trait variability in 65
male and 81 female patients with spina bifida occulta
(SBO) or spina bifida aperta (SBA) against 170
male and 200 female subjects randomly selected Serbian
subjects without these conditions. Variability was
evaluated by direct observation of 15 homozygous recessive
traits (HRT), while gender was evaluated separately.
Individual trait variations between genders in
SBO patients (4/15 HRT) and in SBA patients (12/15
HRT) showed remarkable differences. Individual trait
variations between the male control group and SBO
(9/15 HRT), between the female control group and
SBO (5/15 HRT), between the male control group and
SBA (8/15 HRT), between the female control group
and SBA (9/15 HRT), between male SBO and SBA
patients (6/15 HRT), between female SBO and SBA
patients (6/15 HRT), also indicated remarkable differences.
These differences could be explained by different
expression of genes that may contribute to expression
of spina bifida (SB).
Key words: Spina bifida (SB); Gender; Homozygous
recessive traits (HRT); Variability
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