INDIVIDUAL PHENOTYPE TRAIT VARIABILITY AS GENETIC MARKERS OF GENDER SUSCEPTIBILITY TO SPINA BIFIDA
Nikolic DP1,*, Cvjeticanin S2,3, Petronic I1,2, Brdar R2,4, Cirovic D1,2, Bizic M4, Milincic Z1,2, Karan R5
*Corresponding Author: Dejan P. Nikolic, Physical Medicine and Rehabilitation, University Children’s Hospital, Nikole Stefanovica 3, 11000 Belgrade, Serbia; Tel.: +38-1-638-133-345; Email: denikol27@yahoo.com
page: 11
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Abstract

We compared individual trait variability in 65 male and 81 female patients with spina bifida occulta (SBO) or spina bifida aperta (SBA) against 170 male and 200 female subjects randomly selected Serbian subjects without these conditions. Variability was evaluated by direct observation of 15 homozygous recessive traits (HRT), while gender was evaluated separately. Individual trait variations between genders in SBO patients (4/15 HRT) and in SBA patients (12/15 HRT) showed remarkable differences. Individual trait variations between the male control group and SBO (9/15 HRT), between the female control group and SBO (5/15 HRT), between the male control group and SBA (8/15 HRT), between the female control group and SBA (9/15 HRT), between male SBO and SBA patients (6/15 HRT), between female SBO and SBA patients (6/15 HRT), also indicated remarkable differences. These differences could be explained by different expression of genes that may contribute to expression of spina bifida (SB). Key words: Spina bifida (SB); Gender; Homozygous recessive traits (HRT); Variability



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