APOPTOSIS GENE EXPRESSION PROFILE IN EARLY-STAGE NON SMALL CELL LUNG CANCER
Metodieva SN1, Cherneva RV, Nikolova DN, Genchev GD, Petrov DB, Toncheva DI
*Corresponding Author: Svetlana Nikolova Metodieva, Department of Medical Genetics, Medical University Sofia, 2 Zdrave str, 1431 Sofia, Bulgaria; Tel.: +359-2-952-0357; Fax: +359- 2-952-0357; E-mail: svetlana.metodieva@yahoo.com
page: 47

RESULTS

Using the web-based PCR Array Data Analysis software we calculated the expression of each gene in the tumor tissue compared to the mean value of expression in adjacent non tumor tissues. Genes with altered expression and their average fold regulation values are presented in Table 2. Using the set criterion, none of the 84 analyzed genes were up regulated, while six genes were down regulated in the tumor tissues. Of the underexpressed genes, two were caspases and members of the death effector domain family, CASP8 and CASP10. Other substantially down regulated genes include BCL10 containing caspase recruitment domains (representing the CARD family) and tumor necrosis factor superfamily 8 (TNFSF8), a TNF ligand family member. The death domain-containing gene DAPK1 showed the most stable underexpression being down regulated in eight of the 12 NSCLC cases. From the BCL2 related family members, slight down regulation was shown for MCL1 (Table 2). We performed separate analyses of gene expression in the AC and SCC histological subtypes of NSCLC. In AC, we found the BCL2 family member HRK to be down regulated in five out of seven cases, while in SCC it was up regulated in four out of five cases although it was below the set threshold in three of them. The SCC histotype showed underexpression of DAPK1 in four out of five cases, while four out of seven ACs showed underexpression of this gene.



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