APOPTOSIS GENE EXPRESSION PROFILE IN
EARLY-STAGE NON SMALL CELL LUNG CANCER
Metodieva SN1, Cherneva RV, Nikolova DN,
Genchev GD, Petrov DB, Toncheva DI
*Corresponding Author: Svetlana Nikolova Metodieva, Department of Medical Genetics,
Medical University Sofia, 2 Zdrave str, 1431 Sofia, Bulgaria; Tel.: +359-2-952-0357; Fax: +359-
2-952-0357; E-mail: svetlana.metodieva@yahoo.com
page: 47
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Abstract
Non small cell lung cancer (NSCLC) is a highly
aggressive malignancy with survival rates limited to
some patients in early stages (I and II). Apoptosis
resistance is a hallmark of solid tumors that is tightly
concerned with their biology. We analyzed the
expression of 84 apoptosis-related genes in a group
of Bulgarian patients with early-stage NSCLC.
RNA samples extracted from 12 early-stage
NSCLC patients [five squamous cell carcinomas
(SCC) and seven adenocarcinomas (AC)] and eight
adjacent non neoplastic pulmonary tissues were used
for gene expression analysis. We applied pathwayfocused
expression profiling of 84 apoptosis-related
genes using real-time PCR.
Apoptosis-related genes down regulated in
NSCLC compared to non tumor lung tissue (p <0.05)
included representatives of the tumor necrosis
factor (TNF) ligand family [TNF superfamily 8
(TNFSF8)], caspase cascade (CASP8 and CASP10)
and caspase recruitment domain (CARD) family
(BCL10), the positive apoptosis regulator DAPK1
and BCL2 family member MCL1. The potential of
apoptosis-related genes as prognostic and predictive
markers should be validated in future studies.
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