POLYPLOIDY PHENOMENON AS A CAUSE OF EARLY MISCARRIAGES IN ABORTION MATERIALS
Yildirim ME, Karakus S, Kurtulgan HK, Ozer L, Celik SB
*Corresponding Author: Malik Ejder Yildirim, Associate Professor. Department of Medical Genetics, Faculty of Medicine, Sivas Cumhuriyet University, 58104 Sivas, Turkey. Phone: 03462581085, Email: nemalik2002@gmail.com
page: 5
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Abstract
Objectives: Chromosomal abnormalities are an important
cause of especially early miscarriages. The aim of
this study was to analyze the chromosomal aberrations and
determine the frequencies of numerical and structural chromosome
abnormalities in spontaneous abortion materials.
Methods: This was a prospective research and ninety
two abortion samples obtained from women who had one
or more miscarriages were included in the study. Conventional
karyotype analysis was performed on each sample
to identify possible chromosomal abnormalities.
Results: By karyotype analysis, 11 polyploidy cases,
(9 triploids and 2 tetraploids), 8 trisomies (one of which
was mosaic), 2 monosomies (monosomy X), 1 isochromosome,
1 Xq deletion, and 4 translocations were detected
in abortion materials. Isochromosome and Xq deletion
cases were also mosaic. In addition, five polymorphic
variants were revealed. We found higher paternal age in
polyploidy cases.
Conclusion: The most common anomaly we found in
abortion materials was polyploidy. This was followed by
aneuploidy (trisomy and monosomy). Polyploidy (triploidy
or tetraploidy) emerged as an important cause in cases
of spontaneous abortion. Paternal age may be associated
with polyploidy especially triploidy.
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