IDENTIFICATION OF KEY TARGET GENES AND
PATHWAY ANALYSIS IN NONALCOHOLIC FATTY LIVER
DISEASE VIA INTEGRATED BIOINFORMATICS ANALYSIS
Chen X.1, Zhang L.2, Wang Y.1, Li R.1, Yang M.1, Gao L.3*
*Corresponding Author: Lei Gao, MD, College of Basic Medicine, Changchun University of Chinese
Medicine, 1035 Boshuo, Road, Jingyue District, Changchun City, Jilin Province, 130117, China;
Tel:+ 86-431-8604 5309, Email: gaolei790708@163.com
page: 10
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Abstract
Purpose: This study aimed at exploring the mechanisms
underlying nonalcoholic fatty liver disease (NAFLD)
and developing new diagnostic biomarkers for nonalcoholic
steatohepatitis (NASH). Methods: The microarray
dataset GES83452 was downloaded from the NCBI-GEO
database, and the differentially expressed RNAs (DERs)
were screened between the NAFLD and non-NAFLD
samples of the baseline and 1-year follow-up time point
group based on the Limma package. Results: A total of
561 DERs (268 downregulated and 293 upregulated) were
screened in the baseline time point group, and 1163 DERs
(522 downregulated and 641 upregulated) were screened
in the 1-year follow-up time point group. A total of 74
lncRNA–miRNA pairs and 523 miRNA–mRNA pairs were
obtained in order to construct a lncRNA–miRNA–mRNA
regulatory network. Subsequently, functional enrichment
analysis revealed 28 GO and 9 KEGG pathways in the
ceRNA regulatory network. LEPR and CXCL10 are involved
in the Cytokine–cytokine receptor interaction (P =
1.86E-02), and the FOXO1 is involved in both the insulin
signaling pathway (P = 1.79E-02) and the pathways in
cancer (P = 2.87E-02). Conclusion: LEPR, CXCL10, and
FOXO1 were the characteristic target genes for NAFLD.
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