CHRONIC OBSTRUCTIVE PULMONARY DISEASE RISK
AND SMOKING CESSATION CHANGES INDUCED
BY CHRNA5-A3 AND CHRNB3-A6 VARIATION
IN A CHINESE MALE POPULATION
Zhao L1,, Zou L-Y2,, Cheng B-F3, Yu X-J4, Zou J-H5,*, Han W6,*
*Corresponding Author: Dr. Wei Han, Department of Pulmonary Medicine, Qingdao Municipal Hospital,
Qingdao University, No. 5 Donghai Mid Road, Qingdao, People’s Republic of China. Tel: +86-185-
6185-7838. E-mail: sallyhan1@163.com. And: Dr. Jian-Hong Zou, Center of Diseases Control of Qingdao
Shi-Bei District, No. 3 Deping Road, Qingdao, People’s Republic of China. Tel: +86-185-6185-7599.
E-mail: 277517366@qq.com
-Long Zhao, Ling-Yan Zou contributed equally to this study.
page: 51
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Abstract
Most studies in the field of CHRNA5-A3 and
CHRNB3-A6 have only focused on lung cancer risk; however,
the associations with chronic obstructive pulmonary
disease (COPD) risk and smoking cessation is less understood,
particularly in the Chinese male population. In
this study, samples from 823 male patients with COPD
(non smokers: 416; still smoking: 407) and 435 smoking
male healthy control subjects were performed with DNA
extraction and single nucleotide polymorphism (SNP)
genotyping. We studied three SNPS in two genes, namely
rs667282 and rs3743073 in CHRNA5-A3 and rs4950 in
CHRNB3-A6, and their distributions in the three groups
are not statistically different (p >0.05). We grouped COPD
patients according to whether they had successfully quit
smoking, the CT genotype of rs667282 demonstrated association
with an increased rate of successful smoking
cessation compared with the TT genotype [adjusted odds
ratio (OR) = 0.54, 95% confidence interval (95% CI) =
0.37-0.7, p <0.001); rs4950 AG genotypes were distinctly
associated with increased rates of successful smoking cessation
(adjusted OR = 0.55, 95% CI = 0.40-0.76, p <0.001).
The effect is significant under the assumption of an over
dominant mode of inheritance (adjusted OR = 0.58, 95%
CI = 0.43 to 0.79, p <0.001). No significant difference in
rs3743073 was found (p >0.05). Our findings confirmed
the hypothesis that CHRNA5-A3 and CHRNB3-A6 variation
are not associated with the risk of COPD. We found
CHRNA5-A3 and CHRNB3-A6 were significantly associated
with successful smoking cessation in smoking COPD
patients.
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