PREVALENCE OF CHROMOSOMAL ABNORMALITIES
IN INFERTILE COUPLES IN ROMANIA
Mierla D1,*, Malageanu M1, Tulin R1,2, Albu D1,2
*Corresponding Author: Dana Mierla, PhD, Department of Genetics, Life Memorial Hospital, Grivita Street,
Bucharest, Romania. Tel: +40-72-147-9083. E-mail: dana_mierla@yahoo.com
page: 23
download article in pdf format
|
|
Abstract
The purpose of this study was to establish a correlation
between the presence of chromosomal abnormalities
in one of the partners and infertility. This
retrospective study was performed at the Department
of Reproductive Medicine, Life Memorial Hospital,
Bucharest, Romania, between August 2007 to December
2011. Two thousand, one hundred and ninety-five
patients with reproductive problems were investigated,
and the frequency of chromosomal abnormalities was
calculated. The control group consisting of 87 fertile
persons who had two or more children, was investigated
in this retrospective study. All the patients of this
study were investigated by cytogenetic techniques and
the results of the two groups were compared by a twotailed
Fisher’s exact test. In this study, 94.99% patients
had a normal karyotype and 5.01% had chromosomal
abnormalities (numerical and structural chromosomal
abnormalities). In the study group, numerical chromosomal
abnormalities were detected in 1.14% of infertile
men and 0.62% of infertile women, and structural
chromosomal abnormalities were detected in 1.38% of
infertile men and 1.87% of infertile women, respectively.
The correlation between the incidence of chromosomal
anomalies in the two sexes in couple with
reproductive problems was not statistically significant.
Recently, a possible association between infertility and
chromosomal abnormalities with a significant statistical
association has been reported. Our study shows
that there is no association between chromosomal
abnormalities and infertility, but this study needs to
be confirmed with further investigations and a larger
control group to establish the role of chromosomal
abnormalities in the etiology of infertility.
|
|
|
|
 |
Number 26
VOL. 26(1), 2023 |
Number 25
VOL. 25(2), 2022 |
Number 25
VOL. 25 (1), 2022 |
Number 24
VOL. 24(2), 2021 |
Number 24
VOL. 24(1), 2021 |
Number 23
VOL. 23(2), 2020 |
Number 22
VOL. 22(2), 2019 |
Number 22
VOL. 22(1), 2019 |
Number 22
VOL. 22, 2019 Supplement |
Number 21
VOL. 21(2), 2018 |
Number 21
VOL. 21 (1), 2018 |
Number 21
VOL. 21, 2018 Supplement |
Number 20
VOL. 20 (2), 2017 |
Number 20
VOL. 20 (1), 2017 |
Number 19
VOL. 19 (2), 2016 |
Number 19
VOL. 19 (1), 2016 |
Number 18
VOL. 18 (2), 2015 |
Number 18
VOL. 18 (1), 2015 |
Number 17
VOL. 17 (2), 2014 |
Number 17
VOL. 17 (1), 2014 |
Number 16
VOL. 16 (2), 2013 |
Number 16
VOL. 16 (1), 2013 |
Number 15
VOL. 15 (2), 2012 |
Number 15
VOL. 15, 2012 Supplement |
Number 15
Vol. 15 (1), 2012 |
Number 14
14 - Vol. 14 (2), 2011 |
Number 14
The 9th Balkan Congress of Medical Genetics |
Number 14
14 - Vol. 14 (1), 2011 |
Number 13
Vol. 13 (2), 2010 |
Number 13
Vol.13 (1), 2010 |
Number 12
Vol.12 (2), 2009 |
Number 12
Vol.12 (1), 2009 |
Number 11
Vol.11 (2),2008 |
Number 11
Vol.11 (1),2008 |
Number 10
Vol.10 (2), 2007 |
Number 10
10 (1),2007 |
Number 9
1&2, 2006 |
Number 9
3&4, 2006 |
Number 8
1&2, 2005 |
Number 8
3&4, 2004 |
Number 7
1&2, 2004 |
Number 6
3&4, 2003 |
Number 6
1&2, 2003 |
Number 5
3&4, 2002 |
Number 5
1&2, 2002 |
Number 4
Vol.3 (4), 2000 |
Number 4
Vol.2 (4), 1999 |
Number 4
Vol.1 (4), 1998 |
Number 4
3&4, 2001 |
Number 4
1&2, 2001 |
Number 3
Vol.3 (3), 2000 |
Number 3
Vol.2 (3), 1999 |
Number 3
Vol.1 (3), 1998 |
Number 2
Vol.3(2), 2000 |
Number 2
Vol.1 (2), 1998 |
Number 2
Vol.2 (2), 1999 |
Number 1
Vol.3 (1), 2000 |
Number 1
Vol.2 (1), 1999 |
Number 1
Vol.1 (1), 1998 |
|
|
|
