CAG REPEAT NUMBER IN ANDROGEN RECEPTOR GENE AND MALE INFERTILITY
Plaseski T1,2, Noveski P1, Dimitrovski C2, Kocevska B2, Efremov GD1, Plaseska-Karanfilska D1,*
*Corresponding Author: : Dr. Dijana Plaseska-Karanfilska, Macedonian Academy of Sciences and Arts, Research Center for Genetic Engineering and Biotechnology, Av. Krste Misirkov 2, POB 428, 1000 Skopje, R. Macedonia; Tel: +389 2 3235 410 Fax: +389 2 3115 434; E-mail: dijana@manu.edu.mk
page: 19

RESULTS

The distribution of CAG repeats in the subgroups of infertile/subfertile men and of fertile controls is shown in Figure 3. The range of CAG repeat number, mean CAG repeat length and median for all subgroups is given in Table 1. Mean CAG length did not differ between the subgroups of infertile/subfertile males and the fertile controls. The percentages of long CAG repeats (defined at the cut offs: >26, >27 and >28) are given in Table 2. The highest number of long CAG repeats was found in patients with mild oligozoospermia, the difference being statistically significant when compared to fertile controls.

Figure 1. Genescan profiles of DNA samples with 19, 21, 23 and 26 CAG repeats in exon 1 of the AR gene.

Figure 2. Part of a DNA sequence of exon 1 of the AR gene in a DNA sample with 19 CAG repeats.

 




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