POSSIBLE INTERACTION OF CELL MEMBRANE- BOUND N-ras PATHWAYS WITH NF2-RELATED CYTOSKELETON FACTORS IN ONCOGENESIS OF MENINGIOMAS
Yapijakis C1, Mamali I1, Papapetrou KP2, Stranjalis GS2, Protopapa DP3, Vassilopoulos D1, Sakas DE2
*Corresponding Author: Christos Yapijakis, D.M.D., M.S., Ph.D., Department of Neurology, University of Athens Medical School, Eginition Hospital, Vas Sofias 74, Athens 11528, Greece; Tel: +30-10-7289-125; Fax: +30-10-8811-243; E-mail: cyapijakis_ua_gr@yahoo.com
page: 17

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8. Joachim T, Ram Z, Rappaport ZH, Simon M, Schramm J, Wiestler OD, von Deimling A. Comparative analysis of the NF2, TP53, PTEN, K-RAS, N-RAS and H-RAS genes in sporadic and radiation-induced human meningiomas. Int J Cancer 2001; 94: 218-221.

9. Yapijakis C, Tassiouka K, Stranjalis G, Kotselas V, Davaki P, Sigounas E, Vassilopoulos D. Mutation screening of oncogenes N-ras, erbB-2/neu/ngl/her2 and tumor suppressor gene nf1 in brain tumor biopsies. J Neurosurg (in press).

10. Pedersen-Bjergaard J, Janssen WG, Lyons J, Philip P, Bartram CR. Point mutation of the ras protooncogenes and chromosome aberrations in acute nonlymphocytic leukemia and preleukemia related to therapy with alkylating agents. Cancer Res 1988; 48: 1812-1817.

11. Fasano O, Taparowsky E, Fiddes J, Wigler M, Goldfarb M. Sequence and structure of the coding region of the human H-ras-1 gene from T24 bladder carcinoma cells. J Mol Appl Genet 1983; 2: 173-180.

12. Sainz J, Figueroa K, Baser ME, Mautner VF, Pulst SM. High frequency of nonsense mutations in the NF2 gene caused by C to T transitions in five CGA codons. Hum Molec Genet 1995; 4: 137-139.

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