POSSIBLE INTERACTION OF CELL MEMBRANE- BOUND N-ras PATHWAYS WITH NF2-RELATED CYTOSKELETON FACTORS IN ONCOGENESIS OF MENINGIOMAS
Yapijakis C1, Mamali I1, Papapetrou KP2, Stranjalis GS2, Protopapa DP3, Vassilopoulos D1, Sakas DE2
*Corresponding Author: Christos Yapijakis, D.M.D., M.S., Ph.D., Department of Neurology, University of Athens Medical School, Eginition Hospital, Vas Sofias 74, Athens 11528, Greece; Tel: +30-10-7289-125; Fax: +30-10-8811-243; E-mail: cyapijakis_ua_gr@yahoo.com
page: 17

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2. Zang KD. Cytological and cytogenetical studies on human meningioma. Cancer Genet 1982; 6: 249-274.

3. Trofatter JA, MacCollin MM, Rutter JL, Murrell JR, Duyao MP, Parry DM, Eldridge R, Kley N, Menon AG, Pulaski K, Ramesh V, Jacoby LB, Gusella JF. A novel moesin-, ezrin-, radixin-like gene is a candidate for the neurofibromatosis 2 tumor suppressor. Cell 1993; 72: 791-800.

4. Huson SM, Thrush DC. Central neurofibromatosis. Q Med Rev 1985; 53: 313-324.

5. Hall A, Marshall CJ, Spurr NK, Weiss RA. Identifi­cation of transforming gene in two human sarcoma cell lines as a new member of the ras gene family located on chromosome 1. Nature 1983; 303: 396-400.

6. Boguski MS, McCormick F. Proteins regulating Ras and its relatives. Nature 1993; 366: 643-654.

7. Downward J. Regulatory mechanisms for ras proteins. Bioessays 1992; 14: 177-184.

8. Joachim T, Ram Z, Rappaport ZH, Simon M, Schramm J, Wiestler OD, von Deimling A. Comparative analysis of the NF2, TP53, PTEN, K-RAS, N-RAS and H-RAS genes in sporadic and radiation-induced human meningiomas. Int J Cancer 2001; 94: 218-221.

9. Yapijakis C, Tassiouka K, Stranjalis G, Kotselas V, Davaki P, Sigounas E, Vassilopoulos D. Mutation screening of oncogenes N-ras, erbB-2/neu/ngl/her2 and tumor suppressor gene nf1 in brain tumor biopsies. J Neurosurg (in press).

10. Pedersen-Bjergaard J, Janssen WG, Lyons J, Philip P, Bartram CR. Point mutation of the ras protooncogenes and chromosome aberrations in acute nonlymphocytic leukemia and preleukemia related to therapy with alkylating agents. Cancer Res 1988; 48: 1812-1817.

11. Fasano O, Taparowsky E, Fiddes J, Wigler M, Goldfarb M. Sequence and structure of the coding region of the human H-ras-1 gene from T24 bladder carcinoma cells. J Mol Appl Genet 1983; 2: 173-180.

12. Sainz J, Figueroa K, Baser ME, Mautner VF, Pulst SM. High frequency of nonsense mutations in the NF2 gene caused by C to T transitions in five CGA codons. Hum Molec Genet 1995; 4: 137-139.

13. Cook SJ, Rubinfeld B, Albert I, McCormick F. RapV12 antagonizes Ras-dependent activation of ERK1 and ERK2 by LPA and EGF in Rat-1 fibroblasts. EMBO J 1993; 12: 3475-3485.




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