POSSIBLE INTERACTION OF CELL MEMBRANE- BOUND N-ras PATHWAYS WITH NF2-RELATED CYTOSKELETON FACTORS IN ONCOGENESIS OF MENINGIOMAS
Yapijakis C1, Mamali I1, Papapetrou KP2, Stranjalis GS2, Protopapa DP3, Vassilopoulos D1, Sakas DE2
*Corresponding Author: Christos Yapijakis, D.M.D., M.S., Ph.D., Department of Neurology, University of Athens Medical School, Eginition Hospital, Vas Sofias 74, Athens 11528, Greece; Tel: +30-10-7289-125; Fax: +30-10-8811-243; E-mail: cyapijakis_ua_gr@yahoo.com
page: 17

RESULTS

The results are summarized in Table 1. In 10 (71.4%) of the meningioma samples either mutant NF2 or abnormal expression of N-ras were detected. Analysis of two known hot spot codons of the NF2 gene revealed that four of the 14 meningioma samples (28.6%) had a mutation CGA TGA (ArgStop) at codon 57 in heterozygosity with the normal allele (Fig. 1). No mutant allele was detected in codon 198.

      Normal N-ras protein was immunohistochemically detected at normal intensity in four of the 14 meningiomas  (28.6%), and was not detected in one sample (7.1%). The latter corresponded to a grade I meningioma, obtained from a 65-year-old man. In nine samples, the staining intensity was greater than that of the control (64.3%). Examples of observed N-ras immunohistochemical intensity are shown in Fig. 2.




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