UPDATED MODELING PARAMETERS FOR DOWN’S SYNDROME SCREENING
Cuckle HS*
*Corresponding Author: Professor Howard S. Cuckle, Reproductive Epidemiology, University of Leeds, 3 Gemini Park, Sheepscar Way, Leeds LS7 3JB, North Yorkshire, UK; Tel.: +44-113-284-9230; Fax: +44-113-262-1658; E-mail: h.s.cuckle@leeds.ac.uk
page: 101

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15. Debieve F, Bouckaert A, Hubinont C, Thomas K. Multiple screening for fetal Down's syndrome with the classic triple test, dimeric inhibin A and ultrasound. Gyne­col Obstet Invest 2000; 49(4): 221-226.

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27. Zoppi MA, Ibba RM, Floris M, Monni G. Fetal nuchal translucency screening in 12495 pregnancies in Sardinia. Ultrasound Obstet Gynecol 2001; 18(6): 649-651.

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29. Lam YH, Lee CP, Sin SY, Tang R, Wong HS, Wong SF, Fong DY, Tang MH, Woo HH. Comparison and integration of first trimester fetal nuchal translucency and second trimester maternal serum screening for fetal Down syndrome. Prenat Diagn 2002; 22(8): 730-735.

30. Herman A, Dreazen E, Herman AM, Batukan CE, Holzgreve W, Tercanli S. Bedside estimation of Down syndrome risk during first-trimester ultrasound screening. Ultrasound Obstet Gynecol 2002; 20(5): 468-475.

31. Snijders RJM, Noble P, Sebire N, Souka A, Nico­laides KH. UK multicentre project on assessment of risk of trisomy 21 by maternal age and fetal nuchal-translu­cency thickness at 10-14 weeks of gestation. The Lancet 1998; 352(9125): 343-346.

32. Locatelli A, Piccoli MG, Vergani P, Mariani E, Ghidini A, Mariani S, Pezzullo JC. Critical appraisal of the use of nuchal fold thickness measurements for the prediction of Down syndrome. Am J Obstet Gynecol 2000; 182(1, pt 1): 192-197.

33. Bahado-Singh RO, Oz U, Hsu CD, Deren O, Copel JA, Mahoney MJ. Ratio of nuchal thickness to humerus length for Down syndrome detection. Am J Obstet Gynecol 2001; 184(6): 1284-1288.

34. Souter VL, Nyberg DA, El-Bastawissi A, Zebel­man A, Luthhardt F, Luthy DA. Correlation of ultrasound findings and biochemical markers in the second trimester of pregnancy in fetuses with trisomy 21. Prenat Diagn 2002; 22(3): 175-182.

35. Benn PA, Kaminsky LM, Ying J, Borgida AF, Egan JF. Combined second-trimester biochemical and ultrasound screening for Down syndrome. Obstet Gynecol 2002; 100(6): 1168-1176.

36. Spencer K, Crossley JA, Aitken DA, Nix AB, Dunstan FD, Williams K. Temporal changes in maternal serum biochemical markers of trisomy 21 across the first and second trimester of pregnancy. Ann Clin Biochem 2002; 39(Pt 6): 567-76.

37. Royston P, Thompson SG. Model-based screening by risk with application to Down’s syndrome. Stats in Med 1992; 11(2): 257-268.

38. Cuckle HS, Wald NJ, Thompson SG. Estimating a woman’s risk of having a pregnancy associated with Down’s syndrome using her age and serum a-fetoprotein level. Br J Obstet Gynaecol 1987; 94(5): 387-402.


39. Cuckle HS, Aitken D, Goodburn S, Senior B, Spencer K, Standing S. Age-standardisation for monitor­ing performance in Down’s syndrome screening pro­grammes. Prenat Diagn 2004; in press.




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