UPDATED MODELING PARAMETERS FOR DOWN’S SYNDROME SCREENING
Cuckle HS*
*Corresponding Author: Professor Howard S. Cuckle, Reproductive Epidemiology, University of Leeds, 3 Gemini Park, Sheepscar Way, Leeds LS7 3JB, North Yorkshire, UK; Tel.: +44-113-284-9230; Fax: +44-113-262-1658; E-mail: h.s.cuckle@leeds.ac.uk
page: 101

Abstract

In Down’s syndrome (DS) screening, multi-variate Gaussian modeling is used to estimate the risk of an af­fected pregnancy from the marker profile, maternal age and family history. The most reliable models use parame­ters based on meta-analysis of published studies and tai­lored to the local screening population. In this paper the meta-analysis approach is extended to second trimester inhibin, combining first trimester pregnancy associated plasma protein (PAPP)-A, with second trimester markers, and ultrasound first trimester nuchal translucency (NT)and second trimester nuchal skin-fold (NF) thickness. The existing and updated meta-analysis parameters are used to predict screening performance for the related policies yielding a detection rate for a 5% false-positive as high as 90-93%.

Keywords: Down’s syndrome (DS); Screening; Pa­rameters; Modeling; Performance.




Number 19
VOL. 19 (2), 2016
Number 19
VOL. 19 (1), 2016
Number 18
VOL. 18 (2), 2015
Number 18
VOL. 18 (1), 2015
Number 17
VOL. 17 (2), 2014
Number 17
VOL. 17 (1), 2014
Number 16
VOL. 16 (2), 2013
Number 16
VOL. 16 (1), 2013
Number 15
VOL. 15 (2), 2012
Number 15
VOL. 15, 2012 Supplement
Number 15
Vol. 15 (1), 2012
Number 14
14 - Vol. 14 (2), 2011
Number 14
The 9th Balkan Congress of Medical Genetics
Number 14
14 - Vol. 14 (1), 2011
Number 13
Vol. 13 (2), 2010
Number 13
Vol.13 (1), 2010
Number 12
Vol.12 (2), 2009
Number 12
Vol.12 (1), 2009
Number 11
Vol.11 (2),2008
Number 11
Vol.11 (1),2008
Number 10
Vol.10 (2), 2007
Number 10
10 (1),2007
Number 9
1&2, 2006
Number 9
3&4, 2006
Number 8
1&2, 2005
Number 8
3&4, 2004
Number 7
1&2, 2004
Number 6
3&4, 2003
Number 6
1&2, 2003
Number 5
3&4, 2002
Number 5
1&2, 2002
Number 4
Vol.3 (4), 2000
Number 4
Vol.2 (4), 1999
Number 4
Vol.1 (4), 1998
Number 4
3&4, 2001
Number 4
1&2, 2001
Number 3
Vol.3 (3), 2000
Number 3
Vol.2 (3), 1999
Number 3
Vol.1 (3), 1998
Number 2
Vol.3(2), 2000
Number 2
Vol.1 (2), 1998
Number 2
Vol.2 (2), 1999
Number 1
Vol.3 (1), 2000
Number 1
Vol.2 (1), 1999
Number 1
Vol.1 (1), 1998

 

 


 About the journal ::: Editorial ::: Subscription ::: Information for authors ::: Contact
 Copyright © Balkan Journal of Medical Genetics 2006