ARRAY COMPARATIVE GENOMIC HYBRIDIZATION:
A NEW GENOMIC APPROACH FOR HIGH-RESOLUTION
ANALYSIS OF COPY NUMBER CHANGES
Dimova Iv
*Corresponding Author: Dr. Ivanka Dimova, Department of Medical Genetics, Medical University Sofia, 2 Zdrave str, 1431 Sofia, Bulgaria; Tel.Fax: +359-2-952-03-57; E-mail: idimova73@yahoo.com
page: 11
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FUTURE DIRECTIONS
Altered DNA copy number is one mechanism for the changes in gene expression that underlie developmental abnormalities and cancer. The utility of genomic arrays will increase as the density of coverage of the genome increases. Arrays of contiguous clones for chromosome 8 [35] and chromosome 22 [27] have been reported. Arrays assembled from high-density clone sets allow single copy changes to be determined to ~50 kb. Introduction into the clinic of array-based assays of constitutional chromosomal aberrations and cancer genomes is likely to occur in the near future, and will require consideration of appropriate array designs, platforms and analysis procedures to meet the very stringent demands for reliable and sensitive performance.
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