ASSOCIATION OF CYP2C19*2 C.681G>A (RS4244285) LOSS-OF-FUNCTION ALLELE WITH CARDIOVASCULAR DISEASE RISK IN THE KOSOVO POPULATION
Elshani N1*, Ukella K1, Staninova Stojovska M2, Naumovska Z2, Kurshumliu M3, Gorani D4, Kapedanovska Nestorovska A
*Corresponding Author: Corresponding Author: Nora Elshani, Glloku te Shelgjet “Veternik” 10000-Prishtinë, Kosova. Phone: +38344601032. E-mail: nora.elshani1@gmail.com; nora.elshani@rezonanca-rks.com.
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CONCLUSION
This study identifies a possible association between
the CYP2C19*2 allele and an increased probability of
CVD within the Kosovo population, offering novel in-
sights into the intra-ethnic variability of this LOF allele and
its clinical relevance for PGx-guided therapy within the
region. The findings should be considered when optimiz-
ing the implementation of the clopidogrel PGx testing in
the routine clinical practice at the national level. Further
studies examining the relationship between the CYP2C19
PGx data, patient-specific follow up outcomes, and plasma
concentration of clopidogrel’s active metabolite are neces-
sary to validate these observations and assess the utility of
PGx-guided clopidogrel treatment in Kosovo population.
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